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2024
N-Hydroxypiridinedione: A Privileged Heterocycle for Targeting the HBV RNase H
D Moianos, M Makri, GM Prifti, C Chiotellis, A Pappas, Molly Woodson, Razia Tajwar, John E. Tavis G Zoidis*. N-Hydroxypiridinedione: A Privileged Heterocycle for Targeting the HBV RNase H. Molecules 2024, 29(12), 2942.
New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies
George Fytas,* Grigoris Zoidis,* Antonios Drakopoulos, Martin C. Taylor, John M. Kelly, Alexandra Tsatsaroni, Andrew Tsotinis, Novel lipophilic hydroxamates as promising trypanocidal agents: Design, Synthesis, SAR and Conformational Behavior Studies, ACS Med. Chem. Lett. (2024), 15, 7, 1041–1048.
Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition
Erofili Giannakopoulou, Vasiliki Pardali, Tiffany C. Edwards, Molly Woodson, Razia Tajwar, John E. Tavis, Grigoris Zoidis*. Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition. Antiviral Research, 223 (2024) 105833.
MYC the oncogene from hell: Novel opportunities for cancer therapy
Adriana Papadimitropoulou, Maria Makri, Grigoris Zoidis,* Myc the oncogene from Hell: Novel opportunities for cancer therapy, (2022) European Journal of Medicinal Chemistry, 2024, 267, 116194.
Cyclopeptide alkaloids from the Greek shrub Paliurus spina-christi and their in silico binding affinity to Dipeptidyl Peptidase IV
Vaios Amountzias, Dennis Abatis, Antonios Drakopoulos, Grigoris Zoidis and Nektarios Aligiannis, Cyclopeptide alkaloids from the Greek shrub Paliurus spina-christi and their in silico binding affinity to Dipeptidyl Peptidase IV, Natural Product Research, 1–11, 2024.
Cyclopeptide alkaloids from the Greek shrub Paliurus spina-christi and their in silico binding affinity to Dipeptidyl Peptidase IV
V Pardali, E Giannakopoulou, G Mpekoulis, V Tsopela, G Panos, Martin C. Taylor, John M. Kelly, Niki Vassilaki and Grigoris Zoidis*. Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity. Pharmaceuticals 16 (7), 1046, 2023.
Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
D Moianos, GM Prifti, M Makri, G Zoidis*. Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites, Pharmaceuticals 16 (6), 901, 2023.
Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
Tamer Nasr, Ahmed M. Aboshanab, George Mpekoulis, Antonios Drakopoulos, Niki Vassilaki, Grigoris Zoidis*, Khaled A. M. Abouzid and Wafaa Zaghary, Novel 6-Aminoquinazolinone Derivatives as Potential Cross GT1-4 HCV NS5B Inhibitors, Viruses, 2022, 14, 2767.
Metal coordinating inhibitors of Rift Valley fever virus replication
Elizabeth Geerling, Valerie Murphy, Maria C. Mai, E. Taylor Stone, Andreu Gazquez Casals, Mariah Hassert, Austin T. O’Dea, Feng Cao, Maureen J. Donlin, Mohamed Elagawany, Bahaa Elgendy, Vasiliki Pardali, Erofili Giannakopoulou, Grigoris Zoidis, Daniel V. Schiavone, Alex J. Berkowitz, Nana B. Agyemang, Ryan P. Murelli, John E. Tavis, Amelia K. Pinto, James D. Brien
PLoS ONE, (2022), 17(9 September)
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
J. Hamdy; N. Emadeldin; M.M. Hamed; E. Frakolaki; S. Katsamakas; N. Vassilaki; G. Zoidis; A.K.H. Hirsch; M. Abdel-Halim; A.H. Abadi
Pharmaceuticals, (2022), 15(5), 632
Opioid ligands addressing unconventional binding sites and more than one opioid receptor subtype
A. Drakopoulos, D. Moianos, G.-M. Prifti, G. Zoidis, M. Decker
ChemMedChem, (2022), 17(14)
Design, Synthesis and 5-HT1A Binding Affinity of N-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)tricyclo[3.3.1.13,7]decan-1-amine and N-(3-(4-(2-Methoxyphenyl) piperazin-1-yl)propyl)-3,5-dimethyl-tricylo[3.3.1.13,7]decan-1-amine G. Zoidis, M.I. Loza, M. Catto
Molbank (2022), (1), M1353
Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier
Mennatallah Abdallah, Mostafa M Hamed, Efseveia Frakolaki, Sotirios Katsamakas, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Anna KH Hirsch, Mohammad Abdel-Halim, Ashraf H Abadi
European Journal of Medicinal Chemistry, (2022), 229, 114034
Recent Advances in Hepatitis B Treatment
G.M Prifti, D. Moianos, E. Giannakopoulou, V. Pardali, J.E. Tavis, G. Zoidis
Pharmaceuticals, (2021), 14 (5), 417
The triazole ring as a privileged scaffold for putative antifungals: Synthesis and evaluation of a series of new analogues G. Zoidis, E Kritsi, P Lecinska, M Ivanov, P Zoumpoulakis, M Sokovic, Catto, M.
ChemMedChem, (2021), 16 (1), 134-144
Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates
Abdel Karim, S.E., Youssef, Y.H., Abdel-Halim, M., Frakolaki, E., Vassilaki, N., Zoidis, G., Ahmed, N.S., Abadi, A.H.
Bioorganic Chemistry, (2020), 102, 104089
A multi-technique analytical approach for impurity profiling during synthesis: The case of corticosteroids
Nicolette Sammut Bartolo, Grigoris Zoidis, Evagelos Gikas, Dimitra Benaki, Victor Ferrito, Anthony Serracino-Inglott
Journal of Pharmaceutical and Biomedical Analysis, (2020), 190, 113483
Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study
Vasiliki Pardali, Erofili Giannakopoulou, Dimitrios-Ilias Balourdas, Vassilios Myrianthopoulos, Martin C Taylor, Marina Šekutor, Kata Mlinarić-Majerski, John M Kelly, Grigoris Zoidis
Current Pharmaceutical Design, (2020), 26, 1-29
1,2-Αnnulated Adamantane Heterocyclic Derivatives as Anti-Influenza Α Virus Agents
Pardali, V., Giannakopoulou, E., Konstantinidi, A., Kolocouris, A., Zoidis, G.
Croatica Chemica Acta, (2019), 92(2), 211-228
Novel Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties and Conformational Aspects of the Core Scaffold
Alaa R. S. Leila, Mai H. A. Mousa, Efseveia Frakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim, Ashraf H. Abadi
ACS Omega, (2019), 4, 11440−11454
Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species
Erofili Giannakopoulou, Vasiliki Pardali, Efseveia Frakolaki, Vasileios Siozos, Vassilios Myrianthopoulos, Emmanuel Mikros, Martin C. Taylor, John M. Kelly, Niki Vassilaki and Grigoris Zoidis
Med. Chem. Commun., (2019), 10, 991–1006
Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H
Tavis, J.E., Zoidis, G., Meyers, M.J., Murelli, R.P.
ACS Infectious Diseases, (2019), 5 (5), 655-658
Transesterification instead of N-Alkylation: An Intriguing Reaction
Giannakopoulou, E., Pardali, V., Skrettas, I., Zoidis, G.
ChemistrySelect, (2019), 4, 3195 –3198
Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches
Ramsis, T.M. Abdel Karim, S.E., Vassilaki, N., Frakolaki, E., Kamal, A.A.M., Zoidis, G., Ahmed, N.S., Abadi, A.H.
Archiv der Pharmazie, (2018), 351(7), 1800017
Metal-chelating agents against viruses and parasites
Giannakopoulou, E., Pardali, V., Zoidis, G.
Future Medicinal Chemistry, (2018), 10 (11), 1283-1285
Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study Zoidis, G., Tsotinis, A., Tsatsaroni, A., Taylor, M.C., Kelly, J.M., Efstathiou, A., Smirlis, D., Fytas, G.
Chemical Biology and Drug Design, (2018), 91(2), 408-421
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents Zoidis, G., Sosic, A., Da Ros, S., Gatto, B., Sissi, C., Palluotto, F., Carotti, A., Catto, M.
Bioorganic and Medicinal Chemistry, (2017), 25(9), 2625-2634
Novel indole-flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus Zoidis, G., Giannakopoulou, E., Stevaert, A., Frakolaki, E., Myrianthopoulos, V., Fytas, G., Mavromara, P., Mikros, E., Bartenschlager, R., Vassilaki, N., Naesens, L.
MedChemComm, (2016), 7(3), 447-456
This article is part of themed collection: New Talent: Europe and 2016 MedChemComm Hot Articles and has been selected as front cover page article.
2016
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties
Palluotto, F., Sosic, A., Pinato, O., Zoidis G., Gatto, B., Carotti, A.
European Journal of Medicinal Chemistry, (2016), 123, 704-717
Anti-allodynic effect of 2-(aminomethyl)adamantane-1-carboxylic acid in a rat model of neuropathic pain: A mechanism dependent on CaV2.2 channel inhibition Zoidis, G., Sandoval, A., Pineda-Farias, J.B., Granados-Soto, V., Felix, R.
Bioorganic & Medicinal Chemistry (2014) 22 (6), 1797-1803
An intriguing and facile one-pot catalytic synthesis of N-alkylated lactams Zoidis, G.; Neasens, L., De Clercq, E.
Monatshefte für Chemie - Chemical Monthly (2013) 144 (4), 515–521
Inhibition of recombinant N-type and native high voltage-gated neuronal Ca2+ channels by AdGABA: mechanism of action studies
Martinez-Hernandez, E.; Sandoval, A.; Gonzalez-Ramirez, R.; Zoidis, G.; and Felix, R.
Toxicology and Applied Pharmacology (2010) 250 (3), 270-277
Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus
Fytas, C., Kolocouris, A., Fytas, G., Zoidis, G., Valmas, C., Basler, C.F.
Bioorganic Chemistry (2010) 38 (6), 247-251
Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines Zoidis, G., Kolocouris, N., Kelly, J.M., Prathalingam, S.R., Naesens, L., De Clercq, E.
European Journal of Medicinal Chemistry (2010) 45 (11), 5022-5030
Design and synthesis of trypanocidal 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones
Papanastasiou, I; Tsotinis A.; Zoidis, G.; Kolocouris, N.; John M. Kelly, S. Radhika Prathalingham
ChemMedChem., (2009), 4 (7), 1059-1062
Design and Synthesis of 1,2-Annulated Adamantane Piperidines with Antiviral Activity Zoidis, G.; Kolocouris, N.; Naesens, L. and De Clercq E.
Bioorganic & Medicinal Chemistry, (2009), 17 (4), 1534-1541
Design and synthesis of bioactive 1,2-annulated adamantane derivatives Zoidis, G.; Tsotinis A.; Kolocouris, N.; John M. Kelly, S. Radhika Prathalingham, Lieve Naesens and Erik De Clercq
Org. Biomol. Chem., (2008), 6, 3177-3185
Design and synthesis of bioactive adamantane spiro heterocycles
Nicolas Kolocouris, Grigoris Zoidis, George B. Foscolos, George Fytas, S. Radhika Prathalingham, John M. Kelly, Lieve Naesens and Erik De Clercq
Bioorganic & Medicinal Chemistry Letters (2007), 17, 15, 4358-4362
("Top-cited articles" as published in Bioorganic & Medicinal Chemistry Letters 2003-2010)
Heterocyclic Rimantadine Analogues with Antiviral Activity Grigoris Zoidis, Christos Fytas, Ioannis Papanastasiou, George B. Foscolos, George Fytas, Elizaveta Padalko, Erik De Clercq, Johan Neyts and Nicolas Kolocouris
Bioorganic & Medicinal Chemistry (2006), 14, 10, 3341-3348
The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin Grigoris Zoidis, Ioannis Papanastasiou, Ioannis Dotsikas, Alejandro Sandoval, Raquel Gouvea Dos Santos, Zeta Papadopoulou-Daifoti, Alexander Vamvakides, Nicolas Kolocouris, and Ricardo Felix
Bioorganic & Medicinal Chemistry (2005), 13, 8, 2791-2798
Are the 2-isomers of the drug rimantadine active ant-influenza agents? Zoidis, G.; Kolocouris, N.; Foscolos, G.B.; Kolocouris, A.; Fytas, G.; Karayannis, P.; Padalko, E.; Neyts, J.; De Clercq, E.
Antiviral Chemistry & Chemotherapy (2003), 14, 3, 153-164
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