Publications

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  • 2020
    Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study
    Vasiliki Pardali, Erofili Giannakopoulou, Dimitrios-Ilias Balourdas, Vassilios Myrianthopoulos, Martin C Taylor, Marina Šekutor, Kata Mlinarić-Majerski, John M Kelly, Grigoris Zoidis
    Current Pharmaceutical Design, (2020), 26, 1-29
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  • 2019
    1,2-Αnnulated Adamantane Heterocyclic Derivatives as Anti-Influenza Α Virus Agents
    Pardali, V., Giannakopoulou, E., Konstantinidi, A., Kolocouris, A., Zoidis, G.
    Croatica Chemica Acta, (2019), 92(2), 211-228
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  • 2019
    Novel Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties and Conformational Aspects of the Core Scaffold
    Alaa R. S. Leila, Mai H. A. Mousa, Efseveia Frakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim, Ashraf H. Abadi
    ACS Omega, (2019), 4, 11440−11454
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  • 2019
    Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species
    Erofili Giannakopoulou, Vasiliki Pardali, Efseveia Frakolaki, Vasileios Siozos, Vassilios Myrianthopoulos, Emmanuel Mikros, Martin C. Taylor, John M. Kelly, Niki Vassilaki and Grigoris Zoidis
    Med. Chem. Commun., (2019), 10, 991–1006
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  • 2019
    Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H
    Tavis, J.E., Zoidis, G., Meyers, M.J., Murelli, R.P.
    ACS Infectious Diseases, (2019), 5 (5), 655-658
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  • 2019
    Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents
    Fytas, G., Zoidis, G., Taylor, M.C., Kelly, J.M., Tsatsaroni, A., Tsotinis, A.
    Future Medicinal Chemistry, 11 (11), 1259-1266
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  • 2019
    Transesterification instead of N-Alkylation: An Intriguing Reaction
    Giannakopoulou, E., Pardali, V., Skrettas, I., Zoidis, G.
    ChemistrySelect, (2019), 4, 3195 –3198
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  • 2018
    Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches
    Ramsis, T.M. Abdel Karim, S.E., Vassilaki, N., Frakolaki, E., Kamal, A.A.M., Zoidis, G., Ahmed, N.S., Abadi, A.H.
    Archiv der Pharmazie, (2018), 351(7), 1800017
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  • 2018
    Metal-chelating agents against viruses and parasites
    Giannakopoulou, E., Pardali, V., Zoidis, G.
    Future Medicinal Chemistry, (2018), 10 (11), 1283-1285
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  • 2018
    Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study
    Zoidis, G., Tsotinis, A., Tsatsaroni, A., Taylor, M.C., Kelly, J.M., Efstathiou, A., Smirlis, D., Fytas, G.
    Chemical Biology and Drug Design, (2018), 91(2), 408-421
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  • 2017
    Inhibition of hepatitis B virus replication by N-hydroxyisoquinolinediones and related polyoxygenated heterocycles
    Edwards, T.C., Lomonosova, E., Patel, J.A., Li, Q., Villa, J.A., Gupta, A.K., Morrison, L.A., Bailly, F., Cotelle, P., Giannakopoulou, E., Zoidis, G., Tavis, J.E.
    Antiviral Research, (2017), 143, 205-217
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  • 2017
    Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents
    Zoidis, G., Sosic, A., Da Ros, S., Gatto, B., Sissi, C., Palluotto, F., Carotti, A., Catto, M.
    Bioorganic and Medicinal Chemistry, (2017), 25(9), 2625-2634
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  • 2016
    Novel indole-flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus
    Zoidis, G., Giannakopoulou, E., Stevaert, A., Frakolaki, E., Myrianthopoulos, V., Fytas, G., Mavromara, P., Mikros, E., Bartenschlager, R., Vassilaki, N., Naesens, L.
    MedChemComm, (2016), 7(3), 447-456
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    This article is part of themed collection: New Talent: Europe and 2016 MedChemComm Hot Articles and has been selected as front cover page article.

  • 2016
    Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties
    Palluotto, F., Sosic, A., Pinato, O., Zoidis G., Gatto, B., Carotti, A.
    European Journal of Medicinal Chemistry, (2016), 123, 704-717
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  • 2015
    Novel 1-(2-aryl-2-adamantyl)piperazine derivatives with antiproliferative activity
    Fytas, C., Zoidis, G., Tsotinis, A., Fytas, G., Khan, M.A., Akhtar, S., Rahman, K.M., Thurston, D.E.
    European Journal of Medicinal Chemistry, (2015), 93, 281-290
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  • 2014
    Anti-allodynic effect of 2-(aminomethyl)adamantane-1-carboxylic acid in a rat model of neuropathic pain: A mechanism dependent on CaV2.2 channel inhibition
    Zoidis, G., Sandoval, A., Pineda-Farias, J.B., Granados-Soto, V., Felix, R.
    Bioorganic & Medicinal Chemistry (2014) 22 (6), 1797-1803
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  • 2013
    An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
    Tsatsaroni, A.; Zoidis, G.; Zoumpoulakis, P.; Tsotinis, A.; Taylor, M.C.; Kelly, J.M.; Fytas, G.
    Tetrahedron Letters 54 (2013) 3238–3240
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  • 2013
    An intriguing and facile one-pot catalytic synthesis of N-alkylated lactams
    Zoidis, G.; Neasens, L., De Clercq, E.
    Monatshefte für Chemie - Chemical Monthly (2013) 144 (4), 515–521
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  • 2012
    Design, Synthesis and Molecular Simulations Studies of Dihydrostilbene Derivatives as Potent Tyrosinase Inhibitors
    Vontzalidou, A., Zoidis, G., Chaita, E., Makropoulou, M., Aligiannis, N., Lambrinidis, G., Mikros, E., Skaltsounis, A-L.
    Bioorganic & Medicinal Chemistry Letters (2012) 22 (17) , 5523-5526
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  • 2011
    Facile and Effective Synthesis of Spirocycloalkanones
    Zoidis, G., Kolocouris, N.
    Lett. Org. Chem. (2011) 8 (8), 531-535
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  • 2011
    Novel Lipophilic Acetohydroxamic Acid Derivatives Based on Conformationally Constrained Spiro Carbocyclic 2,6-Diketopiperazine Scaffolds with Potent Trypanocidal Activity
    Fytas, C.; Zoidis, G.; Tzoutzas, N.; Taylor, M. C.; Fytas, G.; Kelly, J. M.
    J. Med. Chem. (2011) 54 (14), 5250-5254
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  • 2010
    Inhibition of recombinant N-type and native high voltage-gated neuronal Ca2+ channels by AdGABA: mechanism of action studies
    Martinez-Hernandez, E.; Sandoval, A.; Gonzalez-Ramirez, R.; Zoidis, G.; and Felix, R.
    Toxicology and Applied Pharmacology (2010) 250 (3), 270-277
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  • 2010
    Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus
    Fytas, C., Kolocouris, A., Fytas, G., Zoidis, G., Valmas, C., Basler, C.F.
    Bioorganic Chemistry (2010) 38 (6), 247-251
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  • 2010
    Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines
    Zoidis, G., Kolocouris, N., Kelly, J.M., Prathalingam, S.R., Naesens, L., De Clercq, E.
    European Journal of Medicinal Chemistry (2010) 45 (11), 5022-5030
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  • 2009
    Design and synthesis of trypanocidal 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones
    Papanastasiou, I; Tsotinis A.; Zoidis, G.; Kolocouris, N.; John M. Kelly, S. Radhika Prathalingham
    ChemMedChem., (2009), 4 (7), 1059-1062
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  • 2009
    Synthesis of 1,2 annulated adamantane heterocycles: structural determination studies of the bioactive cyclic sulfite
    Zoidis, G.; Kolocouris, N.; Benaki, D.; Myrianthopoulos, V.; Mikros, E.; Naesens L. and De Clercq, E.
    Tetrahedron Letters, (2009), 50 (22), 2671-2675
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  • 2009
    Design and Synthesis of 1,2-Annulated Adamantane Piperidines with Antiviral Activity
    Zoidis, G.; Kolocouris, N.; Naesens, L. and De Clercq E.
    Bioorganic & Medicinal Chemistry, (2009), 17 (4), 1534-1541
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  • 2008
    Design and synthesis of bioactive 1,2-annulated adamantane derivatives
    Zoidis, G.; Tsotinis A.; Kolocouris, N.; John M. Kelly, S. Radhika Prathalingham, Lieve Naesens and Erik De Clercq
    Org. Biomol. Chem., (2008), 6, 3177-3185
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  • 2008
    A facile and effective synthesis of lipophilic 2,6-diketopiperazine analogues
    Fytas, C.; Zoidis, G.; Fytas, G.
    Tetrahedron (2008), 64, 6749-6754
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  • 2007
    Design and synthesis of bioactive adamantane spiro heterocycles
    Nicolas Kolocouris, Grigoris Zoidis, George B. Foscolos, George Fytas, S. Radhika Prathalingham, John M. Kelly, Lieve Naesens and Erik De Clercq
    Bioorganic & Medicinal Chemistry Letters (2007), 17, 15, 4358-4362
    ("Top-cited articles" as published in Bioorganic & Medicinal Chemistry Letters 2003-2010)
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  • 2007
    Facile synthetic routes to 2-oxo-1-adamantanalkanoic acids
    Kolocouris, N.; Zoidis, G.; Fytas, C.
    Synlett (2007), 7, 1063-1066
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  • 2006
    Heterocyclic Rimantadine Analogues with Antiviral Activity
    Grigoris Zoidis, Christos Fytas, Ioannis Papanastasiou, George B. Foscolos, George Fytas, Elizaveta Padalko, Erik De Clercq, Johan Neyts and Nicolas Kolocouris
    Bioorganic & Medicinal Chemistry (2006), 14, 10, 3341-3348
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  • 2005
    The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin
    Grigoris Zoidis, Ioannis Papanastasiou, Ioannis Dotsikas, Alejandro Sandoval, Raquel Gouvea Dos Santos, Zeta Papadopoulou-Daifoti, Alexander Vamvakides, Nicolas Kolocouris, and Ricardo Felix
    Bioorganic & Medicinal Chemistry (2005), 13, 8, 2791-2798
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  • 2003
    Are the 2-isomers of the drug rimantadine active ant-influenza agents?
    Zoidis, G.; Kolocouris, N.; Foscolos, G.B.; Kolocouris, A.; Fytas, G.; Karayannis, P.; Padalko, E.; Neyts, J.; De Clercq, E.
    Antiviral Chemistry & Chemotherapy (2003), 14, 3, 153-164
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  • 2002
    New 2-(1-Adamantylcarbonyl)pyridine and 1-Acetyladamantane Thiosemicarbazones-Thiocarbonohydrazones: Cell Growth Inhibitory, Antiviral and Antimicrobial Activity Evaluation
    Kolocouris, A.; Dimas, K.; Pannecouque C.; Witvrow, M.; Foscolos, G.B.; Stamatiou, G.; Fytas, G.; Zoidis, G.; Kolocouris, N.; Andrei, G.; Snoeck, R.; De Clercq, E.
    Bioorganic & Medicinal Chemistry Letters (2002), 12, 5, 723-727
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Book Chapters

  • 2002
    Food and Laboratory Safety Technological Institute of Athens
    Zoidis G (2002)