OPEN POSITIONS

There are open positions in my lab for post-graduate research which can lead to the Master's or PhD degrees.

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Students holding an MSc thesis in related subjects and have interest in:

 (a) Computational Drug Design and Development methods;

 (b) Protein X-ray Crystallography;

 (c) Computational and Experimental Biophysics, like DSC and solid-state NMR,

are encouraged to interact with us. Currently there is no funding but opportunity may also exist through State-fellowships application.

Contact: Antonios Kolocouris, Associate Professor of Medicinal and Organic Chemistry, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, NKUA, e-mail: ankol@pharm.uoa.gr

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The projects can include:
A) Organic synthesis of bioactive compounds against influenza A and herpes simplex viruses and peptides corresponding to influenza A/M2TM (22-46) using solid phase peptide synthesis (in collaboration). Drug targets include influenza A/M2TM receptor and adenosine receptor.
B) Biomolecular simulations (Docking and scoring, virtual screening, MD and FEP/MD simulations etc).
C) NMR spectroscopy for studying: (a) The interactions between ligands and their receptor using 19F NMR spectroscopy in micelles (in collaboration). (b) The conformational properties and the structure of ligands (1D or 2D NMR spectra, Dynamic NMR Spectroscopy etc).
D) Biophysical chemistry of ligands and M2TM receptor in lipid bilayers (solid state NMR spectroscopy, SAXS in collaboration).
E) Computational organic chemistry. Ab initio and DFT calculations of weak intramolecular interactions, organic reaction mechanisms.
Students can be trained to one or more of the above techniques according to their specific interests, skills and enthusiasm.

In addition short diploma projects can be included in a project including for example:
a) The synthesis of aminoadamantane derivatives as potential anti-influenza A agents.
b) Docking of aminoadamantane derivatives to M2TM. MD simulations for optimization of docking poses.

Students can apply for fellowships to stay for some period in a collaborative lab in Europe. The can also choose a project in collaboration with Professor Thomas Mavromoustakos (http://users.uoa.gr/~tmavrom/) for collaborative work in NMR spectroscopy and/or Biophysical Chemistry.

Organic Synthesis Lab		NMR Spectroscopy
Computational Chemistry, structure-based drug design