Research
Catalysis |
We design, synthesize, and mechanistically study the function of organometallic complexes, coordination compounds, organocatalysts, and other catalytic systems that catalyze fundamentally interesting and useful chemical and electrochemical transformations.
|
 |
Selected Relevant Publications
Zorba, L. P.; Stylianakis, I.; Tsoureas, N.; Kolocouris, A.; Vougioukalakis, G. C.* J. Org. Chem. 2024, 89, doi.org/10.1021/acs.joc.4c00394. “Copper-Catalyzed One-Pot Synthesis of Thiazolidin-2-Imines”
Tzouras, N. V.; Zorba, L. P.; Kaplanai, E.; Tsoureas, N.; Nelson, D. J.; Nolan, S. P.;* Vougioukalakis, G. C.* ACS Catal. 2023, 13, 8845-8860. “Hexafluoroisopropanol (HFIP) as a multifunctional agent in gold-catalyzed cycloisomerizations and sequential transfor-mations”
Giannopoulos, D. K.; Zorba, L. P.; Zisis, C.; Pitsikalis, M.;* Vougioukalakis, G. C.* Eur. Polym. J. 2023, 191, 112056. “A3 polycondensation: A multicomponent step-growth polymerization reaction for the synthesis of polymeric propargylamines”
Tzouras, N. V.; Gobbo, A.; Pozsoni, N. B.; Chalkidis, S. G.; Bhandary, S.; Van Hecke, K.; Vougioukalakis, G. C.;* Nolan, S. P.* Chem. Commun. 2022, 58, 8516-8519. “Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerizations in hexafluoroisopropanol (HFIP)”
Zorba, L. P.; Egana, E.; Gomez-Bengoa, E.; Vougioukalakis, G. C.* ACS Omega 2021, 6, 23329-23346. “Zinc Iodide Catalyzed Synthesis of Trisubstituted Allenes from Terminal Alkynes and Ketones”
Zorba, L. P.; Vougioukalakis, G. C.* Coord. Chem. Rev. 2021, 429, 213603. “The Ketone-Amine-Alkyne (KA2) Coupling Reaction: Transition Metal-Catalyzed Synthesis of Quaternary Propargylamines”
Neofotistos, S. P.; Tzouras, N. V.; Pauze, M.; Gomez-Bengoa, E.; Vougioukalakis, G. C.* Adv. Synth. Catal. 2020, 362, 3872-3885. “Manganese-Catalyzed Multicomponent Synthesis of Tetrasubstituted Propargylamines: System Development and Theoretical Study”
Tzouras, N. V.; Neofotistos, S. P.; Vougioukalakis, G. C.* ACS Omega 2019, 4, 10279-10292. “Zn-Catalyzed Multicomponent KA2 Coupling: One-Pot Assembly of Propargylamines Bearing Tetrasubstituted Carbon Centers”
Papastavrou, A. T.; Pauze, M.; Gomez-Bengoa, E.; Vougioukalakis, G. C.* ChemCatChem 2019, 11, 5379-5386. “Unprecedented Multicomponent Organocatalytic Synthesis of Propargylic Esters via CO2 Activation”
Tzouras, N. V.; Stamatopoulos, I. K.; Papastavrou, A. T.; Liori, A.; Vougioukalakis, G. C.* Coord. Chem. Rev. 2017, 343, 25-138. “Sustainable Metal Catalysis in C-H Activation”
Pinaka, A.; Vougioukalakis, G. C.* Coord. Chem. Rev. 2015, 288, 69-97. “Using Sustainable Metals to Carry out "Green" Transformations: Fe- and Cu-Catalyzed CO2 Monetization”
Vougioukalakis, G. C.* Chem. Eur. J. 2012, 18, 8868-8880. “Removing Ruthenium Residues from Olefin Metathesis Reaction Products”
Vougioukalakis, G. C.; Grubbs, R. H.* Chem. Rev. 2010, 110, 1746-1787. “Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts”
Vougioukalakis, G. C.; Grubbs, R. H.* J. Am. Chem. Soc. 2008, 130, 2234-2245. “Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands”
|
|
 |
Energy Conversion, Chemosensors, and Nanotechnology |
We synthesize nanostructures, typically containing organic compounds, coordination compounds, fullerenes, and/or graphene nanoribbons, mostly related to energy issues and nanotechnology.
|
 |
Selected Relevant Publications
Bukke, R. N.; Syzgantseva, O. A.; Syzgantseva, M. A.; Aidinis, K.; Soultati, A.; Verykios, A.; Tountas, M.; Psycharis, V.; Alshahrani, T.; Ullah, H.; Zorba, L. P.; Vougioukalakis, G. C.; Wang, J.; Bao, X.; Jang, J.; Nazeeruddin, M. K.;* Vasilopoulou, M.;* Yusoff, A. R. M.* Nature Electronics 2024, doi.org/10.1038/s41928-024-01165-5. “Strain relaxation and multidentate anchoring in n-type perovskite transistors and logical circuits”
Rotas, G.;* Antoniou, G.; Papagiorgis, P.; Basu, A.; Panidi, J.; Ufimkin, P.; Tsetseris, L.; Itskos, G,; Heeney, M.; Vougioukalakis, G. C.; Anthopoulos, T. D.; Keivanidis, P. E.* J. Mater. Chem. C. 2022, 10, 12751-12764. “Doping-induced decomposition of organic semiconductors: a caveat to the use of Lewis acid p-dopants”
Vasilopoulou, M.;* Rashid bin Mohd Yusoff, A.;* Daboczi. M.; Conforto, J.; Ximim Gavim, A. E.; Jose da Silva, W.; Gerniski Macedo, A.; Soultati, A.; Pistolis, G.; Schneider, F. K.; Dong, Y.; Jacoutot, P.; Rotas, G.; Jang, J.; Vougioukalakis, G. C.; Chochos, C. L.;* Kim, J. S.; Gasparini, N.* Nature Commun. 2021, 12, 4868. “High efficiency blue organic light-emitting diodes with below-bandgap electroluminescence”
McLoughlin, C. K.; Kotroni, E.; Bregnhøj, M.; Rotas, G.; Vougioukalakis, G. C.;* Ogilby, P. R.* Sensors 2020, 20, 5172. “Oxygen- and pH-Dependent Photophysics of Fluorinated Fluorescein Derivatives: Non-Symmetrical vs. Symmetrical Fluorination”
Kabanakis, A. N.; Bidikoudi, M.; Elsenety, M. M.; Vougioukalakis, G. C.;* Falaras, P.* Dyes and Pigments 2019, 165, 308-318. “Synthesis of Novel Semi-Squaraine Derivatives and Application in Efficient Dye-Sensitized Solar Cells”
Manthou, V. S.; Perganti, D.; Rotas, G.; Falaras, P.;* Vougioukalakis, G. C.* Synlett 2017, 28, 929-933. “5-Alkyl-8-hydroxyquinolines: Synthesis and Application in Dye-Sensitized Solar Cells”
Sklavounos, A. A.; Pefkianakis, E. K.; Toubanaki, D. K.; Vougioukalakis, G. C.;* Calokerinos, A. C.* ChemPlusChem 2016, 81, 913-916. “A Squaraine Derivative for Cost-Effective, Quick and Highly Sensitive Determination of Mercury and Thiols and pH Sensing”
Manthou, V. S.; Pefkianakis, E. K.; Falaras, P.;* Vougioukalakis, G. C.* ChemSusChem 2015, 8, 588-599. “Coadsorbents: a Key Component in Efficient and Robust Dye-Sensitized Solar Cells”
Vougioukalakis, G. C.;* Konstantakou, M.; Pefkianakis, E. K.; Kabanakis, A. N.; Stergiopoulos, T.; Kontos, A. G.; Andreopoulou, A. K.; Kallitsis, J. K.; Falaras, P.* Asian J. Org. Chem. 2014, 3, 953-962. “A Novel Ruthenium-Based Light-Harvesting Antenna Bearing an Anthracene Moiety in Dye-Sensitized Solar Cells”
Vougioukalakis, G. C.;* Stergiopoulos, T.; Kontos, A. G.; Pefkianakis, E. K.; Papadopoulos, K.; Falaras, P.* Dalton Trans. 2013, 42, 6582-6591. “Novel Ru(II) Sensitizers bearing an Unsymmetrical Pyridine-Quinoline Hybrid Ligand with Extended π-Conjugation: Synthesis and Application in Dye-Sensitized Solar Cells”
|
|
|
Compounds of Biological Significance |
We design, synthesize, and study organic and coordination compounds of biological relevance and potential applications (photodynamic therapy, enzyme inhibition, DNA intercalation, mitochondrial targeting and mitochondrial nanocarriers, endoplasmic reticulum targeting, cellular immunology, etc.).
|
 |
Selected Relevant Publications
Mavroeidi, P.; Zorba, L. P.; Tzouras, N. V.; Neofotistos, S. P.; Georgiou, N.; Sahin, K.; Senturk, M.; Durdagi, S.;* Vougioukalakis, G. C.;* Mavromoustakos, T.* Molecules 2024, in press. “Are terminal alkynes necessary for MAO-A/MAO-B inhibition? A new scaffold is revealed”
Rodriguez-Muniz, G. M.; Mikroulis, T.; Pantelia, A.; Rotas, G.; Consuelo Cuquerella, M.; Vougioukalakis, G. C.;* Miranda, M. A.* Molecules 2022, 27, 1245. “Modulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols”
Mikroulis, T.; Consuelo Cuquerella, M.; Giussani, A.; Pantelia, A.; Rodriguez-Muniz, G. M.; Rotas, G.; Roca-Sanjuan, D.;* Miranda, M. A.;* Vougioukalakis, G. C.* J. Org. Chem. 2021, 86, 11388-11398. “Building a Functionalizable, Potent Chemiluminescent Agent: A Rational Design Study on 6,8-Substituted Luminol Derivatives”
Pantelia, A.; Daskalaki, I.; Consuelo Cuquerella, M.; Rotas, G.; Miranda, M. A.;* Vougioukalakis, G. C.* Molecules 2019, 24, 3957. “Synthesis and Chemiluminescent Properties of Amino-Acylated luminol Derivatives Bearing Phosphonium Cations”
Pefkianakis, E. K.; Theodossiou, T. A.;* Toubanaki, D. K.; Karagouni, E.; Falaras, P.; Papadopoulos, K.; Vougioukalakis, G. C.* Photochem. Photobiol. 2015, 91, 1191-1202. “A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers”
Pefkianakis, E. K.; Christodouleas, D.; Giokas, D. L.; Papadopoulos, K.;* Vougioukalakis, G. C.* Eur. J. Inorg. Chem. 2013, 4628-4635. “A New Family of Ru(II) Photosensitizers with High Singlet Oxygen Quantum Yield: Synthesis, Characterization, and Evaluation”
Vrantza, D.; Kaloudis, P.; Leondiadis, L.; Gimisis, T.;* Vougioukalakis, G. C.; Orfanopoulos, M.; Gasparutto, D.; Cadet, J.; Encinas, S.; Paris, C.; Miranda, M. A.* Helv. Chim. Acta 2006, 89, 2371-2386. “Modification of the Guanine Base with Photolabile N-Hydroxypyridine-2(1H)-thione: Monomer Synthesis, Oligonucleotide Elaboration and Photochemical Studies”
Chatgilialoglu, C.;* Caminal, C.; Altieri, A.; Vougioukalakis, G. C.; Mulazzani, Q. G.; Gimisis, T.; Guerra, M.* J. Am. Chem. Soc. 2006, 128, 13796-13805. “Tautomerism in the Guanyl Radical”
|
|
|
sp2 Carbon Compounds |
We develop synthetic and functionalization methodologies for graphene nanoribbons, carbon nanotubes, fullerene C60, and heterofullerenes.
|
 |
Selected Relevant Publications
Canton-Vitoria, R.;* Kagoura, A.; Tonis, E.; Heliopoulos, N.; Galeou, A.; Prombona, A.; Stamatakis, K.; Boukos, N.; Siamidis, D.; Vougioukalakis, G. C.;* Tagmatarchis, N.* Mater. Today Chem. 2024, 37, 102041. “Covalent post-functionalization of Kevlar with graphene oxide-melamine for UV-light protection and antibacterial properties”
Fakharuddin, A.;* Armadorou, K. K.; Zorba, L. P.; Tountas, M.; Seewald, T.; Soultati, A.; Tsipas, P.; Schütz, E. R.; Tzoganakis, N.; Panagiotakis, S.; Yannakopoulou, K.; Dimoulas, A.; Psycharis, V.; Kymakis, E.; Yusoff, A. R. M.; Aidinis, K.; Schmidt-Mende, L.; Vougioukalakis, G. C.;* Nazeeruddin, M. K.;* Vasilopoulou, M.* Chin. J. Chem. 2023, 41, 431-442. “A Triethyleneglycol C60 Mono-adduct Derivative for Efficient Electron Transport in Inverted Perovskite Solar Cells”
Pefkianakis, E. K.; Manthou, V. S.; Paraskevopoulou, P.; Sakellariou, G.; Vougioukalakis, G. C.* ChemistrySelect 2016, 6, 1232-1238. “A New Family of Fullerene Derivatives Bearing Long Alkyl and Triethyleneglycol Moieties”
Pefkianakis, E. K.; Sakellariou, G.; Vougioukalakis, G. C.* ARKIVOC 2015, iii, 167-192. “Chemical Synthesis of Graphene Nanoribbons”
Roubelakis, M. M.; Vougioukalakis, G. C.* “Surgery at the Molecular Level: Synthesis and Modifications of Open-Cage Fullerene Derivatives” in Handbook of Carbon Nano Materials, Volume 3 (Medicinal and Bio-related Applications), D'Souza, F.; Kadish, K. M., Eds., World Scientific Publishing, 2012, p. 233-294. (Invited Author)
Vougioukalakis, G. C.;* Roubelakis, M. M.; Orfanopoulos, M.* Chem. Soc. Rev. 2010, 39, 817-844. “Open-Cage Fullerenes: Towards the Construction of Nanosized Molecular Containers”
Vougioukalakis, G. C.; Roubelakis, M. M.; Orfanopoulos, M.* J. Org. Chem. 2010, 75, 4124-4130. “Radical Reactivity of Aza[60]fullerene: Preparation of Monoadducts and Limitations”
Vougioukalakis, G. C.; Orfanopoulos, M.* J. Am. Chem. Soc. 2004, 126, 15956-15957. “Photoinduced Electron Transfer Reactivity of Aza[60]fullerene: Three Discrete Functionalization Pathways with a Single Substrate”
|
|
|
