Georgios C. Vougioukalakis Research Publications Group Members Collaborators Research Programs Teaching Join Us




We design, synthesize, and mechanistically study the function of organometallic complexes, coordination compounds, organocatalysts, and other catalytic systems that catalyze fundamentally interesting and useful chemical and electrochemical transformations.

Selected Relevant Publications

  • Tzouras, N. V.; Zorba, L. P.; Kaplanai, E.; Tsoureas, N.; Nelson, D. J.; Nolan, S. P.;* Vougioukalakis, G. C.* ACS Catal. 2023, 13, 8845-8860. “Hexafluoroisopropanol (HFIP) as a multifunctional agent in gold-catalyzed cycloisomerizations and sequential transfor-mations

  • Giannopoulos, D. K.; Zorba, L. P.; Zisis, C.; Pitsikalis, M.;* Vougioukalakis, G. C.* Eur. Polym. J. 2023, 191, 112056. “A3 polycondensation: A multicomponent step-growth polymerization reaction for the synthesis of polymeric propargylamines

  • Tzouras, N. V.; Gobbo, A.; Pozsoni, N. B.; Chalkidis, S. G.; Bhandary, S.; Van Hecke, K.; Vougioukalakis, G. C.;* Nolan, S. P.* Chem. Commun. 2022, 58, 8516-8519. “Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerizations in hexafluoroisopropanol (HFIP)

  • Zorba, L. P.; Egana, E.; Gomez-Bengoa, E.; Vougioukalakis, G. C.* ACS Omega 2021, 6, 23329-23346. “Zinc Iodide Catalyzed Synthesis of Trisubstituted Allenes from Terminal Alkynes and Ketones

  • Zorba, L. P.; Vougioukalakis, G. C.* Coord. Chem. Rev. 2021, 429, 213603. “The Ketone-Amine-Alkyne (KA2) Coupling Reaction: Transition Metal-Catalyzed Synthesis of Quaternary Propargylamines

  • Neofotistos, S. P.; Tzouras, N. V.; Pauze, M.; Gomez-Bengoa, E.; Vougioukalakis, G. C.* Adv. Synth. Catal. 2020, 362, 3872-3885. “Manganese-Catalyzed Multicomponent Synthesis of Tetrasubstituted Propargylamines: System Development and Theoretical Study

  • Tzouras, N. V.; Neofotistos, S. P.; Vougioukalakis, G. C.* ACS Omega 2019, 4, 10279-10292. “Zn-Catalyzed Multicomponent KA2 Coupling: One-Pot Assembly of Propargylamines Bearing Tetrasubstituted Carbon Centers

  • Papastavrou, A. T.; Pauze, M.; Gomez-Bengoa, E.; Vougioukalakis, G. C.* ChemCatChem 2019, 11, 5379-5386. “Unprecedented Multicomponent Organocatalytic Synthesis of Propargylic Esters via CO2 Activation

  • Tzouras, N. V.; Stamatopoulos, I. K.; Papastavrou, A. T.; Liori, A.; Vougioukalakis, G. C.* Coord. Chem. Rev. 2017, 343, 25-138. “Sustainable Metal Catalysis in C-H Activation

  • Pinaka, A.; Vougioukalakis, G. C.* Coord. Chem. Rev. 2015, 288, 69-97. “Using Sustainable Metals to Carry out "Green" Transformations: Fe- and Cu-Catalyzed CO2 Monetization

  • Vougioukalakis, G. C.* Chem. Eur. J. 2012, 18, 8868-8880. “Removing Ruthenium Residues from Olefin Metathesis Reaction Products

  • Vougioukalakis, G. C.; Grubbs, R. H.* Chem. Rev. 2010, 110, 1746-1787. “Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts

  • Vougioukalakis, G. C.; Grubbs, R. H.* J. Am. Chem. Soc. 2008, 130, 2234-2245. “Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands

  • Energy Conversion, Chemosensors, and Nanotechnology

    We synthesize nanostructures, typically containing organic compounds, coordination compounds, fullerenes, and/or graphene nanoribbons, mostly related to energy issues and nanotechnology.

    Selected Relevant Publications

  • Rotas, G.;* Antoniou, G.; Papagiorgis, P.; Basu, A.; Panidi, J.; Ufimkin, P.; Tsetseris, L.; Itskos, G,; Heeney, M.; Vougioukalakis, G. C.; Anthopoulos, T. D.; Keivanidis, P. E.* J. Mater. Chem. C. 2022, 10, 12751-12764. “Doping-induced decomposition of organic semiconductors: a caveat to the use of Lewis acid p-dopants

  • Vasilopoulou, M.;* Rashid bin Mohd Yusoff, A.;* Daboczi. M.; Conforto, J.; Ximim Gavim, A. E.; Jose da Silva, W.; Gerniski Macedo, A.; Soultati, A.; Pistolis, G.; Schneider, F. K.; Dong, Y.; Jacoutot, P.; Rotas, G.; Jang, J.; Vougioukalakis, G. C.; Chochos, C. L.;* Kim, J. S.; Gasparini, N.* Nature Commun. 2021, 12, 4868. “High efficiency blue organic light-emitting diodes with below-bandgap electroluminescence

  • McLoughlin, C. K.; Kotroni, E.; Bregnhøj, M.; Rotas, G.; Vougioukalakis, G. C.;* Ogilby, P. R.* Sensors 2020, 20, 5172. “Oxygen- and pH-Dependent Photophysics of Fluorinated Fluorescein Derivatives: Non-Symmetrical vs. Symmetrical Fluorination

  • Kabanakis, A. N.; Bidikoudi, M.; Elsenety, M. M.; Vougioukalakis, G. C.;* Falaras, P.* Dyes and Pigments 2019, 165, 308-318. “Synthesis of Novel Semi-Squaraine Derivatives and Application in Efficient Dye-Sensitized Solar Cells

  • Manthou, V. S.; Perganti, D.; Rotas, G.; Falaras, P.;* Vougioukalakis, G. C.* Synlett 2017, 28, 929-933. “5-Alkyl-8-hydroxyquinolines: Synthesis and Application in Dye-Sensitized Solar Cells

  • Sklavounos, A. A.; Pefkianakis, E. K.; Toubanaki, D. K.; Vougioukalakis, G. C.;* Calokerinos, A. C.* ChemPlusChem 2016, 81, 913-916. “A Squaraine Derivative for Cost-Effective, Quick and Highly Sensitive Determination of Mercury and Thiols and pH Sensing

  • Manthou, V. S.; Pefkianakis, E. K.; Falaras, P.;* Vougioukalakis, G. C.* ChemSusChem 2015, 8, 588-599. “Coadsorbents: a Key Component in Efficient and Robust Dye-Sensitized Solar Cells

  • Vougioukalakis, G. C.;* Konstantakou, M.; Pefkianakis, E. K.; Kabanakis, A. N.; Stergiopoulos, T.; Kontos, A. G.; Andreopoulou, A. K.; Kallitsis, J. K.; Falaras, P.* Asian J. Org. Chem. 2014, 3, 953-962. “A Novel Ruthenium-Based Light-Harvesting Antenna Bearing an Anthracene Moiety in Dye-Sensitized Solar Cells

  • Vougioukalakis, G. C.;* Stergiopoulos, T.; Kontos, A. G.; Pefkianakis, E. K.; Papadopoulos, K.; Falaras, P.* Dalton Trans. 2013, 42, 6582-6591. “Novel Ru(II) Sensitizers bearing an Unsymmetrical Pyridine-Quinoline Hybrid Ligand with Extended π-Conjugation: Synthesis and Application in Dye-Sensitized Solar Cells

  • Compounds of Biological Significance

    We design, synthesize, and study organic and coordination compounds of biological relevance and potential applications (photodynamic therapy, enzyme inhibition, DNA intercalation, mitochondrial targeting and mitochondrial nanocarriers, endoplasmic reticulum targeting, cellular immunology, etc.).

    Selected Relevant Publications

  • Rodriguez-Muniz, G. M.; Mikroulis, T.; Pantelia, A.; Rotas, G.; Consuelo Cuquerella, M.; Vougioukalakis, G. C.;* Miranda, M. A.* Molecules 2022, 27, 1245. “Modulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols

  • Mikroulis, T.; Consuelo Cuquerella, M.; Giussani, A.; Pantelia, A.; Rodriguez-Muniz, G. M.; Rotas, G.; Roca-Sanjuan, D.;* Miranda, M. A.;* Vougioukalakis, G. C.* J. Org. Chem. 2021, 86, 11388-11398. “Building a Functionalizable, Potent Chemiluminescent Agent: A Rational Design Study on 6,8-Substituted Luminol Derivatives

  • Pantelia, A.; Daskalaki, I.; Consuelo Cuquerella, M.; Rotas, G.; Miranda, M. A.;* Vougioukalakis, G. C.* Molecules 2019, 24, 3957. “Synthesis and Chemiluminescent Properties of Amino-Acylated luminol Derivatives Bearing Phosphonium Cations

  • Pefkianakis, E. K.; Theodossiou, T. A.;* Toubanaki, D. K.; Karagouni, E.; Falaras, P.; Papadopoulos, K.; Vougioukalakis, G. C.* Photochem. Photobiol. 2015, 91, 1191-1202. “A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers

  • Pefkianakis, E. K.; Christodouleas, D.; Giokas, D. L.; Papadopoulos, K.;* Vougioukalakis, G. C.* Eur. J. Inorg. Chem. 2013, 4628-4635. “A New Family of Ru(II) Photosensitizers with High Singlet Oxygen Quantum Yield: Synthesis, Characterization, and Evaluation

  • Vrantza, D.; Kaloudis, P.; Leondiadis, L.; Gimisis, T.;* Vougioukalakis, G. C.; Orfanopoulos, M.; Gasparutto, D.; Cadet, J.; Encinas, S.; Paris, C.; Miranda, M. A.* Helv. Chim. Acta 2006, 89, 2371-2386. “Modification of the Guanine Base with Photolabile N-Hydroxypyridine-2(1H)-thione: Monomer Synthesis, Oligonucleotide Elaboration and Photochemical Studies

  • Chatgilialoglu, C.;* Caminal, C.; Altieri, A.; Vougioukalakis, G. C.; Mulazzani, Q. G.; Gimisis, T.; Guerra, M.* J. Am. Chem. Soc. 2006, 128, 13796-13805. “Tautomerism in the Guanyl Radical

  • sp2 Carbon Compounds

    We develop synthetic and functionalization methodologies for graphene nanoribbons, carbon nanotubes, fullerene C60, and heterofullerenes.

    Selected Relevant Publications

  • Fakharuddin, A.;* Armadorou, K. K.; Zorba, L. P.; Tountas, M.; Seewald, T.; Soultati, A.; Tsipas, P.; Schütz, E. R.; Tzoganakis, N.; Panagiotakis, S.; Yannakopoulou, K.; Dimoulas, A.; Psycharis, V.; Kymakis, E.; Yusoff, A. R. M.; Aidinis, K.; Schmidt-Mende, L.; Vougioukalakis, G. C.;* Nazeeruddin, M. K.;* Vasilopoulou, M.* Chin. J. Chem. 2023, 41, 431-442. “A Triethyleneglycol C60 Mono-adduct Derivative for Efficient Electron Transport in Inverted Perovskite Solar Cells

  • Pefkianakis, E. K.; Manthou, V. S.; Paraskevopoulou, P.; Sakellariou, G.; Vougioukalakis, G. C.* ChemistrySelect 2016, 6, 1232-1238. “A New Family of Fullerene Derivatives Bearing Long Alkyl and Triethyleneglycol Moieties

  • Pefkianakis, E. K.; Sakellariou, G.; Vougioukalakis, G. C.* ARKIVOC 2015, iii, 167-192. “Chemical Synthesis of Graphene Nanoribbons

  • Roubelakis, M. M.; Vougioukalakis, G. C.* “Surgery at the Molecular Level: Synthesis and Modifications of Open-Cage Fullerene Derivatives” in Handbook of Carbon Nano Materials, Volume 3 (Medicinal and Bio-related Applications), D'Souza, F.; Kadish, K. M., Eds., World Scientific Publishing, 2012, p. 233-294. (Invited Author)

  • Vougioukalakis, G. C.;* Roubelakis, M. M.; Orfanopoulos, M.* Chem. Soc. Rev. 2010, 39, 817-844. “Open-Cage Fullerenes: Towards the Construction of Nanosized Molecular Containers

  • Vougioukalakis, G. C.; Roubelakis, M. M.; Orfanopoulos, M.* J. Org. Chem. 2010, 75, 4124-4130. “Radical Reactivity of Aza[60]fullerene: Preparation of Monoadducts and Limitations

  • Vougioukalakis, G. C.; Orfanopoulos, M.* J. Am. Chem. Soc. 2004, 126, 15956-15957. “Photoinduced Electron Transfer Reactivity of Aza[60]fullerene: Three Discrete Functionalization Pathways with a Single Substrate

  • Design: gcv & AlexSk