2016
1. “Progesterone-induced acrosome exocytosis requires sequential involvement of calcium-independent phospholipase A2â (iPLA2â) and group X secreted phospholipase A2 (sPLA2)” Abi Nahed R., Martinez G., Escoffier J., Yassine S., Karaouzène T., Hograindleur J. P., Turk J., Kokotos G., Ray P. F., Bottari S., Lambeau G., Hennebicq S., Arnoult C. J. Biol. Chem. 2016, 291, 3076-3089.
2. “Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations” Vasilakaki S., Barbayianni E., Leonis G., Papadopoulos M. G., Mavromoustakos T., Gelb M. H., Kokotos G. Bioorg. Med. Chem. 2016, 24, 1683-1695.
3. “Computer aided drug design approaches for identification of novel autotaxin (ATX) inhibitors” E. Vrontaki, G. Melagraki, E. Kaffe, T. Mavromoustakos, G. Kokotos, V. Aidinis, A. Afantitis, Curr. Med. Chem. 2016, 23, 1708-1724.
4. “Development of potent and selective inhibitors for Group VIA calcium-independent phospholipase A2 quided by molecular dynamics and structure-activity relationships” V. D. Mouchlis, D. Limnios, M. G. Kokotou, E. Barbayianni, G. Kokotos, J. A. McCammon, E. A. Dennis, J. Med. Chem. 2016, 59, 4403-4414.
5. “Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells” S. Vasilakaki, E. Barbayianni, V. Magrioti, O. Pastukhov, V. Constantinou-Kokotou, A. Huwiler, G. Kokotos, Bioorg. Med. Chem. 2016, 24, 3029-3034.
6. “2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity” G. Antonopoulou, V. Magrioti, M. Kokotou, A. Nikolaou, E. Barbayianni, V. D. Mouchlis, E. A. Dennis, G. Kokotos Bioorg. Med. Chem. 2016, 24, 4544-4554.
7. “Efficient microwave-assisted synthesis of hydroxymethyl ketones using NHC organocatalysts” A. Nikolaou, G. Kokotos, V. Magrioti Tetrahedron 2016, 72, 7628-7632.
8. “Inhibitors of phospholipase A2 and their therapeutic potentials: an update on patents (2012-2016)” M. G. Kokotou, D. Limnios, A. Nikolaou, A. Psarra, G. Kokotos, Exp. Opin. Ther. Patents, accepted.
9. "Inhibition of secreted phospholipases A2 by 2-oxoamides based on α-amino acids: synthesis, in vitro evaluation and molecular docking calculations" V. D. Mouchlis, V. Magrioti, E. Barbayianni, N. Cermak, R. C. Oslund, T. M. Mavromoustakos, M. H. Gelb, G. Kokotos, Bioorg. Med. Chem. 2011, 19, 735-743.
10. "Prolinamides carrying a thiourea group as catalysts for the asymmetric aldol reaction" S. Fotaras, C. G. Kokotos, E. Tsandi, G. Kokotos, Eur. J. Org. Chem. 2011, 1310-1317.
11. "Novel pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as highly effective catalysts for the asymmetric Michael addition" C. G. Kokotos, D. Limnios, D. Triggidou, M. Trifonidou, G. Kokotos, Org. Biomol. Chem. 2011, 9, 3386-3395.
12. "The application of rational design on phospholipase A2 inhibitors" V. D. Mouchlis, E. Barbayianni, T. M. Mavromoustakos, G. Kokotos Curr. Med. Chem. 2011, 18, 2566-2582.
13. "Phospholipase A2 superfamily members play divergent roles after spinal cord injury" R. Lopez-Vales, N. Ghasemlou, A. Redensek, B. J. Kerr, E. Barbayianni, G. Antonopoulou, C. Baskakis, K. I. Rathore, V. Constantinou-Kokotou, D. Stephens, T. Shimizu, E.A. Dennis, G. Kokotos, S. David FASEB J. 2011, 25, 4240- 4252.
14. "Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention" E. A. Dennis, J. Cao, Y.-H. Hsu, V. Magrioti, G. Kokotos Chem. Rev. 2011, 111, 6130-6185.
15. "Binding conformation of 2-oxoamide inhibitors to group iva cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics" V. D. Mouchlis, T. M. Mavromoustakos, G. Kokotos J. Chem. Inf. Model. 2012, 52, 243?254.
16. "Primary amine-thioureas with improved catalytic properties for "difficult" michael reactions: efficient organocatalytic syntheses of (S)-baclofen, (R)-baclofen and (S)-phenibut" M. Tsakos, C. G. Kokotos, G. Kokotos Adv. Synth. Catal. 2012, 354, 740-746.
17. "Biocatalyzed regio- and chemoselective ester cleavage: synthesis of bioactive molecules" E. Barbayianni, G. Kokotos ChemCatChem 2012, 4, 592-608.
18. "Potent and selective 2-oxoamide inhibitors of phospholipases A2 as novel medicinal agents for the treatment of inflammatory diseases" E. Barbayianni, G. Antonopoulou, G. Kokotos Pure Appl. Chem. 2012, 84, 1877-1894.
19. "A tripeptide-like prolinamide-thiourea as an aldol reaction catalyst" S. Fotaras, C. G. Kokotos, G. Kokotos Org. Biomol. Chem., 2012, 10, 5613-5619.
20. "Characterization of FKGK18 as inhibitor of group via Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes" T. Ali, G. Kokotos, V. Magrioti, R. N. Bone, J. A. Mobley, W. Hancock, S. Ramanadham PLOS ONE 2013, 8, e71748.
21. "Autotaxin inhibitors: a patent review" E. Barbayianni, V. Magrioti, P. Moutevelis-Minakakis, G. Kokotos Expert Opin. Ther. Patents 2013, 23, 1123-1132.
22. "Fluoroketone inhibition of Ca2+-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics" Y. H. Hsu, D. Bucher, J. Cao, S. Li, S. W. Yang, G. Kokotos, V. L. Woods, J. A. McCammon, E. A. Dennis J. Am. Chem. Soc. 2013, 135, 1330-1337.
23. "Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010-present)" V. Magrioti, G. Kokotos Expert Opin. Ther. Patents 2013, 23, 333-344.
24. "New potent and selective polyfluoroalkyl ketone inhibitors of gvia calcium-independent phospholipase A2" V. Magrioti, A. Nikolaou, A. Smyrniotou, I. Shah, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos Bioorg. Med. Chem. 2013, 21, 5823-5829.
25. "Cytosolic group via mouse peritoneal macrophages phospholipid pools in zymosan-stimulated phospholipase A2s act on distinct calcium-independent group VIA" L. Gil-de-G?mez, A. M. Astudillo, C. Guijas, V. Magrioti, G. Kokotos, M. A. Balboa, J. Balsinde J. Immunol. 2014, 192, 752-762.
26. "Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo." Kokotos G, Feuerherm A. J, Barbayianni E, Shah I, S?ther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis E. A, Johansen B. J. Med. Chem. 2014, 57, 7523.
27. "Inhibition of Ca2+-independent phospholipase A2 (iPLA2b) amelioretes islet infiltration and incidence of diabetes in nod mice." Bone R. N, Gai Y, Magrioti V, Kokotou M. G, Ali T, Lei X, Tse H. M, Kokotos G, Ramanadham S. Diabetes 2015, 64, 541-554.
28. "Functionalized multi-walled carbon nanotubes in an aldol reaction" D. Chronopoulos, C. G. Kokotos, N. Karousis, G. Kokotos, N. Tagmatarchis Nanoscale 2015, 7, 2750-2757.
29. "Rational drug design paradigms: the odyssey for designing better drugs" T. Kellici, D. Ntountaniotis, E. Vrontaki, G. Liapakis, P. Minakakis, G. Kokotos, S. Hadjikakou, A.G. Tzakos, A. Afantitis, G. Melagraki, V. Di Marzo, T. Mavromoustakos Combinatorial Chemistry & High Throughput Screening, 2015, 18, 238-256.
30. "Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer" E. Barbayanni, E. Kaffe, V. Aidinis, G. Kokotos Progr. Lipid Res. 2015, 58, 76-96.
31. "Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders" W.-Y. Ong, T. Farooqui, G. Kokotos, A. A. Farooqui ACS Chemical Neuroscience 2015, 6, 814-831.
32. "Conjugating proline derivatives onto multi-walled carbon nanotubes: Preparation, characterization and catalytic activity in water" Chronopoulos D. D., Kokotos C. G.,Tsakos M., Karousis N., Kokotos G., Tagmatarchis, N. Materials Lett. 2015, 157, 212-214.
33. "Synthesis of a palladium complex with a β-d-glucopyranosyl-thiosemicarbazone and its application in the Suzuki-Miyaura coupling of aryl bromides with phenylboronic acid" Tenchiu A.-C., Ventouri I.-K., Ntasi G., Palles D., Kokotos G., Kovala-Demertzi D., Kostas I. D. Inorg. Chim. Acta 2015, 435, 142-146.
34. “SYSTEMIC AND INTRATHECAL EFFECTS OF A NOVEL SERIES OF PHOSPHOLIPASE A2 INHIBITORS ON HYPERALGESIA AND SPINAL PGE2 RELEASE” T.L.Yaksh, G. Kokotos, C.I. Svensson, D. Stephens, C. G. Kokotos, B. Fitzsimmons, D. Hadjipavlou-Litina, X.Y. Hua and E.A. Dennis, J. Pharmacol. Exp. Ther., 316, 466-475, 2006.
35. “PROLINATES AS SECONDARY AMINES IN AMINOCARBONYLATION: SYNTHESIS OF N-ACYLATED PROLINATES” E. Takacs, R. Skoda-Foldes, P. Acs, E. Muller, G. Kokotos and L. Kollar, Lett. Org. Chem., 3, 62-67, 2006.
36. “SYNTHESIS OF TETRAZOLE ANALOGUES OF ã- AND ä-AMINO ACIDS” P. Moutevelis-Minakakis, M. Filippakou, C. Sinanoglou and G. Kokotos, J. Peptide Sci., 12, 377-382, 2006.
37. “SYNTHETIC INHIBITORS OF GROUP IVA AND GROUP VIA PHOSPHOLIPASE A2” V. Magrioti and G. Kokotos, Anti-Inflammatory Anti-Allergy Agents Med. Chem., 5, 189-203, 2006.
38. “DIFFERENTIAL INHIBITON OF GROUP IVA AND GROUP VIA PHOSPHOLIPASE A2 BY 2-OXOAMIDES” D. Stephens, E. Barbayianni, V. Constantinou-Kokotou, A. Peristeraki, D. A. Six, J. Cooper, R. Harkewicz, R. A. Deems, E. A. Dennis and G. Kokotos, J. Med. Chem., 49, 2821-2828, 2006.
39. “THREE GENERATIONS OF á,ã-DIAMINOBUTYRIC ACID MODIFIED POLY(PROPYLENEIMINE) DENDRIMERS AND THEIR CISPLATIN-TYPE PLATINUM COMPLEXES” E. Bellis, L. Hajba, B. Kovacs, K. Sandor, L. Kollar and G. Kokotos, J. Biochem. Biophys. Meth., 69, 151-156, 2006.
40. “ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS. 3. FAST REMOVAL OF ALLYL AND CHLOROETHYL ESTERS BY BACILLUS SUBTILIS ESTERASE (BS2)” I. Fotakopoulou, E. Barbayianni, V. Constantinou-Kokotou, U. T. Bornscheuer and G. Kokotos, J. Org. Chem., 72, 782-786, 2007.
41. “STRUCTURE-ACTIVITY RELATIONSHIP OF 2-OXOAMIDE INHIBITION OF GROUP IV A CYTOSOLIC PHOSPHOLIPASE A2 AND GROUP V SECRETED PHOSPHOLIPASE A2” D. A. Six, E. Barbayianni, V. Loukas, V. Constantinou-Kokotou, D. Hadjipavlou-Litina, D. Stephens, A. C. Wong, V. Magrioti, P. Moutevelis-Minakakis, S. F. Baker, E. A. Dennis and G. Kokotos, J. Med. Chem., 50, 4222-4235, 2007.
42. “SYNTHESIS OF LIPOPHILIC 2-OXOAMIDES BASED ON ã-AMINOBUTYRIC AND ä-AMINOVALERIC ANALOGUES AND THEIR ACTIVITY AGAINST PHOSPHOLIPASE A2” P. Moutevelis-Minakakis, A. Neokosmidi, M. Filippakou, D. Stephens, E. A. Dennis and G. Kokotos, J. Pept. Sci., 13, 634-641, 2007.
43. “SYNTHESIS OF 2-OXOAMIDES BASED ON SULFONAMIDE ANALOGUES OF ã-AMINO ACIDS AND THEIR ACTIVITY ON PHOSPHOLIPASE A2” G. Antonopoulou, V. Magrioti, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis and G. Kokotos J. Pept. Sci., 14, 1111-1120, 2008.
44. “INTRACELLULAR PHOSPHOLIPASE A2 GROUP IVA AND GROUP VIA PLAY IMPORTANT ROLES IN WALLERIAN DEGENERATION AND AXON REGENERATION AFTER PERIPHERAL NERVE INJURY” R. López-Vales, X. Navarro, T. Shimizu, C. Baskakis, G. Kokotos, V. Constantinou-Kokotou, D. Stephens, E. A. Dennis and S. David Brain, 13, 2620-2630, 2008.
45. “A NOVEL MONOACYLGLYCEROL LIPASE INHIBITOR WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY” V. Magrioti, G. Naxakis, D. Hadjipavlou-Litina, A. Makriyannis, G. Kokotos, Bioorg. Med. Chem. Lett., 18, 5424-5427, 2008.
46. “HOMOGENEOUS CATALYTIC AMINOCARBONYLATION OF 1-IODO-1-DODECENE. THE FACILE SYNTHESIS OF ODD-NUMBER CARBOXAMIDES VIA PALLADIUM-CATALYSED AMINO-CARBONYLATION” A. Takács, P. Ács, R. Farkas, G. Kokotos, and L. Kollár, Tetrahedron, 64, 9874-9878, 2008.
47. “SYNTHESIS OF MEDICINALLY INTERESTING POLYFLUOROKETONES VIA PERFLUOROALKYL LITHIUM REAGENTS” C. G. Kokotos, C. Baskakis and G. Kokotos, J. Org. Chem, 73, 8623-8626, 2008.
48. “SYNTHESIS OF POLYFLUORO KETONES FOR SELECTIVE INHIBITION OF HUMAN PHOSPHOLIPASE A2 ENZYMES” C. Baskakis, V. Magrioti, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis and G. Kokotos J. Med. Chem, 51, 8027-8037, 2008.
49. “STRUCTURE-ACTIVITY RELATIONSHIPS OF NATURAL AND NON-NATURAL AMINO ACID-BASED AMIDE AND 2-OXOAMIDE INHIBITORS OF HUMAN PHOSPHOLIPASE A2 ENZYMES” G. Antonopoulou, E. Barbayianni, V. Magrioti, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis, and G. Kokotos, Bioorg. Med. Chem., 16, 10257-10269, 2008.
50. “LIPOLYTIC ENZYMES AS THERAPEUTIC TARGETS” G. Kokotos, Eur. J. Lipid Sci. Technol., 110, 1081-1083, 2008.
51. “SULFONAMIDES OF HOMOPROLINE AND DIPEPTIDES AS ORGANOCATALYSTS FOR MICHAEL AND ALDOL REACTIONS” E. Tsanti, C. G. Kokotos, S. Kousidou, V. Ragoussis and G. Kokotos, Tetrahedron, 65, 1444-1449, 2009.
52. “ STRUCTURAL CHARACTERISTICS OF ANABOLIC ANTOGENIC STEROIDS CONTRIBUTING TO BINDING TO THE ANDROGEN RECEPTOR AND TO THEIR ANABOLIC AND ANDROGENIC ACTIVITIES APPLIED MODIFICATIONS IN THE STEROIDAL STRUCTURE” A. Fragaki, Y. Angelis, M. Koupparis, A. Tsantili-Kakoulidou, G. Kokotos and C. Georgakopoulos, Steroids, 74, 172-197, 2009.
53. “DIFFERENT PHOSPHOLIPASE A2s AFFECT DISTINCT PHASES OF CNS AUTOIMMUNE DISEASE – EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS” A. Kalyvas, C. Baskakis, V. Magrioti, V. Constantinou-Kokotou, D. Stephens, E. A. Dennis, G. Kokotos and S. David Brain 132, 1221-1235, 2009.
54. “SYNTHESIS OF HOMOPROLINE ANALOGUES CONTAINING HETEROCYCLIC RINGS AND THEIR ACTIVITY AS ORGANOCATALYSTS FOR MICHAEL REACTION” E. Barbayianni, P. Bouzi, V. Constantinou-Kokotou, V. Ragoussis, and G. Kokotos, Heterocycles, 78, 1243-1252, 2009.
55. “ANTHRANILIC ACID BASED CCK1 RECEPTOR ANTAGONISTS: BLOCKING THE RECEPTOR WITH THE SAME 'WORDS' OF THE ENDOGENOUS LIGAND” L. Lassiani, M.V. Pavan, F. Berti, G. Kokotos, T. Markidis, L. Mennuni, F. Makovec, A. Varnavas, Bioorg. Med. Chem. 2009, 17, 2336-2350.
56. “2-OXOAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDODIPEPTIDES” E. Barbayianni, D. Stephens, A. Grkovich, V. Magrioti, Y.-H. Hsu, N. Cotton, P. Dolatzas, D. Kalogiannidis, E. A. Dennis, and G. Kokotos, Bioorg. Med. Chem. 2009, 17, 4833-4843.
57. “APPLICATION OF 3D QSAR COMFA/COMSIA AND IN SILICO DOCKING STUDIES ON NOVEL RENIN INHIBITORS AGAINST CARDIOVASCULAR DISEASES” A. Politi, S. Durdagi, P. Moutevelis-Minakakis, G. Kokotos, M.G. Papadopoulos, T. Mavromoustakos, Eur. J. Med. Chem. 2009, 44, 3703-3711.
58. “PRIMARY AMINE-THIOUREAS BASED ON TERT-BUTYL ESTERS OF NATURAL AMINO ACIDS AS ORGANOCATALYSTS FOR MICHAEL REACTION” C. G. Kokotos and G. Kokotos, Adv. Synth. Catal. 2009, 351, 1355-1362.
59. “INHIBITOR BINDING OF GROUP IVA PHOSPHOLIPASE A2 PROBED BY MOLECULAR DYNAMICS AND DEUTERIUM EXCHANGE MASS SPECTROMETRY” J. E. Burke, A. Babakhani, A. A. Gorfe, G. Kokotos, S. Li, V. L. Woods, J. A. McCammon, and E. A. Dennis, J. Am. Chem. Soc. 2009, 131, 8083-8091.
60. “STUDY OF THE REMOVAL OF ALLYL ESTERS BY CANDIDA ANTARCTICA LIPASE B (CAL-B) AND PIG LIVER ESTERASE (PLE)” K. Thodi, E. Barbayianni, I. Fotakopoulou, U. T. Bornscheuer, V. Constantinou-Kokotou, P. Moutevelis-Minakakis, and G. Kokotos, J. Mol. Catal. B: Enzymatic, 2009, 61, 241-246.
61. “BACILLUS SUBTILIS ESTERASE (BS2) AND ITS DOUBLE MUTANT HAVE DIFFERENT SELECTIVITY IN THE REMOVAL OF CARBOXYL PROTECTING GROUPS” E. Barbayianni, C. G. Kokotos, S. Bartsch, C. Drakou, U. T. Bornscheuer, and G. Kokotos, Adv. Synth. Catal. 2009, 351, 2325-2332.
62. “PHOSPHOLIPASE A2 INHIBITORS AS POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF INFLAMMATORY DISEASES” V. Magrioti and G. Kokotos, Exp. Opin. Ther. Patents 2010, 20, 1-18.
63. “RESOLUTION OF N-PROTECTED AMINO ALCOHOLS BY PORCINE PANCREATIC LIPASE” V. Magrioti, I. Fotakopoulou, N. Athinaios, P. Anastasopoulou, V. Constantinou-Kokotou and G. Kokotos, Lett. Org. Chem. 2010, 7, 159-162.
64. “DESIGN OF NEW SECRETED PHOSPHOLIPASE A2 INHIBITORS BASED ON DOCKING CALCULATIONS BY MODIFYING THE PHARMACOPHORE SEGMENTS OF THE FPL67047XX INHIBITOR” V.D. Mouchlis, T. M. Mavromoustakos and G. Kokotos, J. Comput. Aid. Mol. Des. 2010, 24, 107-115.
65. “POTENT AND SELECTIVE FLUOROKETONE INHIBITORS OF GROUP VIA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2” G. Kokotos, Y.-H. Hsu, J. E. Burke, C. Baskakis, C. G. Kokotos, V. Magrioti and E. A. Dennis, J. Med. Chem. 2010, 53, 3602-3610.
66. “HYPERTENSION STUDY IN ANAESTHETIZED RABBITS: PROTOCOL PROPOSAL FOR AT 1 ANTAGONISTS SCREENING” A.P. Politi, M.V. Zervou, H. Triantafyllidi, P. G. Zoumpoulakis, T. M. Mavromoustakos, A. A. Zoga, P. Moutevelis-Minakakis, G. Kokotos, E. K. Iliodromitis and D. T. Kremastinos, J. Renin-Angio.-Aldo. S. 2010, 11, 103-110.
67. “MOLECULAR DOCKING AND 3D-QSAR COMFA STUDIES ON INDOLE INHIBITORS OF GIIA SECRETED PHOSPHOLIPASE A2” V.D. Mouchlis, T. M. Mavromoustakos and G. Kokotos, J. Chem. Inf. Model. 2010, 50, 1589-1601.
68. “DEVELOPMENT OF ACCURATE BINDING AFFINITY PREDICTIONS OF NOVEL RENIN INHIBITORS THROUGH MOLECULAR DOCKING STUDIES” A. Politi, S. Durdagi, P. Moutevelis-Minakakis, G. Kokotos and T. Mavromoustakos, J. Mol. Graph. Model. 2010, 29, 425–435.
69. “SYNTHESIS AND STUDY OF A LIPOPHILIC -KETO AMIDE INHIBITOR OF PANCREATIC LIPASE”. A. Chiou, T. Markidis,V. Constantinou-Kokotou, R. Verger and G. Kokotos, Org. Lett., 2, 347-350, 2000.
70. “STUDY OF DNA INTERACTIONS WITH MELPHALAN, BUSULPHAN, AND ANALOGUES USING AN HPLC METHOD”. G. Karikas, V. Constantinou-Kokotou, V. Magrioti and G. Kokotos, J. Liq. Chrom. & Rel. Technol., 23, 1859-1864, 2000.
71. “SYNTHESIS AND FLUORESCENCE PROPERTIES OF INTRAMOLECULARLY QUENCHED FLUOROGENIC p-NITROANILIDES CONTAINING COUMARIN OR QUINOLINONE DERIVATIVES AS FLUOROPHORES” C. Charitos, C. Tzougraki and G. Kokotos, J. Peptide Res., 56, 373-381, 2000.
72. “SYNTHESIS OF 2-OXO AMIDE TRIACYLGLYCEROL ANALOGUES AND STUDY OF THEIR INHIBITION EFFECT ON PANCREATIC AND GASTRIC LIPASES” G. Kokotos, R. Verger, A. Chiou, Chemistry-A European Journal, 6, 4211-4217, 2000.
73. "INHIBITION OF LIPOPROTEIN LIPASE BY ALKANESULFONYL FLUORIDES" G. Kokotos, S. Kotsovolou, V. Constantinou-Kokotou, G. Wu and G. Olivecrona, Bioorg. Med. Chem. Lett., 10, 2803-2806, 2000.
74. “BIFUNCTIONAL COUMARIN DERIVATIVES IN SOLUTION AND SOLID PHASE SYNTHESIS OF FLUOROGENIC ENZYME SUBSTRATES” C. Charitos, G. Kokotos and C. Tzougraki, J. Heterocyclic Chem., 38, 153-158, 2001.
75. "A NOVEL APPROACH TO THE SYNTHESIS OF CHIRAL TERMINAL 1,2-DIAMINES" T. Markidis and G. Kokotos, J. Org. Chem., 66, 1919-1923, 2001.
76. "BIS-2-OXOAMIDE TRIACYLGLYCEROL ANALOGUES: A NOVEL CLASS OF POTENT HUMAN GASTRIC LIPASE INHIBITORS" S. Kotsovolou, A. Chiou, R. Verger and G. Kokotos, J. Org. Chem., 66, 962-967, 2001.
77. "SYNTHESIS AND IN VITRO CYTOTOXICITY OF NOVEL LONG CHAIN BUSULPHAN ANALOGUES" G. Kokotos, V.Constantinou-Kokotou, J. M. Padron and G. J. Peters, Bioorg. Med. Chem. Lett., 11, 861-863, 2001.
78. "SYNTHETIC ROUTES AND LIPASE-INHIBITING ACTIVITY OF LONG CHAIN á-KETO AMIDES" A. Chiou, R. Verger and G. Kokotos, Lipids, 36, 535-542, 2001.
79. "STUDY OF AMINOGLYCOSIDE - NUCLEIC ACID INTERACTIONS BY AN HPLC METHOD" V.Constantinou-Kokotou, G. Karikas and G. Kokotos, Bioorg. Med. Chem. Lett., 11, 1015-1018, 2001.
80. " SYNTHESIS AND IN VITRO CYTOTOXICITY OF LONG CHAIN 2-AMINO ALCOHOLS AND 1,2-DIAMINES" T. Markidis, J. M. Padron, V. S. Martin, G. J. Peters and G. Kokotos, Anticancer Res., 21, 2835-2840, 2001.
81. "SYNTHESIS OF ENANTIOPURE NON-NATURAL á-AMINO ACIDS USING TERT-BUTYL (2S)-2-[BIS-(TERT-BUTYLOXYCARBONYL)AMINO]-5-OXO-PENTANOATE AS KEY INTERMEDIATE: THE FIRST SYNTHESIS OF (S)-2-AMINO OLEIC ACID", V. Constantinou-Kokotou, V. Magrioti, T. Markidis, G. Kokotos, J. Peptide. Res., 58, 325-331, 2001.
82. "SYNTHESIS OF ENANTIOPURE ù-FUNCTIONALIZED C15 á-AMINO CARBOXYLATES", T. Markidis and G. Kokotos, J. Org. Chem., 67, 1685-1688, 2002.
83. "NOVEL 2-OXOAMIDE INHIBITORS OF HUMAN GROUP IVA PHOSPHOLIPASE A2", G. Kokotos, S. Kotsovolou, D.A. Six, V. Constantinou-Kokotou, C.C. Beltzner, E.A. Dennis, J. Med. Chem., 45, 2891-2893, 2002.
84. "SYNTHESIS OF LIPOPHILIC ALDEHYDES AND STUDY OF THEIR INHIBITION EFFECT ON HUMAN DIGESTIVE LIPASES", S. Kotsovolou, R. Verger, G. Kokotos, Org. Lett., 4, 2625-2628, 2002.
85. "SYNTHESIS OF CHIRAL n,n+1-DIAMINO ACIDS AND THEIR APPLICATION TO THE CONSTRUCTION OF DENDRIMERS", E. Bellis, T. Markidis, G. Kokotos, Synthesis, 1359-1364, 2002.
86. "AN EFFICIENT METHOD FOR THE SYNTHESIS OF ENANTIOPURE ù-AMINO ACIDS WITH PROTEINOGENIC SIDE CHAINS", C. Noula, V. Loukas, G. Kokotos, Synthesis, 1375-1379, 2002.
87. "AMINO ACIDS BASED SYNTHESIS OF CHIRAL LONG CHAIN DIAMINES AND TETRAMINES", V. Loukas, T. Markidis, G. Kokotos, Molecules, 7, 767-776, 2002.
88. "EFFICIENT PROTOCOLS FOR THE SYNTHESIS OF ENANTIOPURE ã-AMINO ACIDS WITH PROTEINOGENIC SIDE CHAINS", V. Loukas, C. Noula, G. Kokotos, J. Peptide Sci., 9, 312-319, 2003.
89. "NOVEL TRIFLUOROMETHYL KETONES AS POTENT GASTRIC LIPASE INHIBITORS", G. Kokotos, S. Kotsovolou, R. Verger, ChemBioChem, 4, 90-95, 2003.
90. "INHIBITION OF DIGESTIVE LIPASES BY 2-OXO AMIDE TRIACYLGLYCEROL ANALOGUES", G. Kokotos, J. Mol. Cat. B Enzym., 22, 255-269, 2003.
91. "SYNTHESIS OF 2-AMINO ALCOHOLS AND UNNATURAL AMINO ACIDS FROM SERINE", V. Magrioti, G. Antonopoulou, E. Pantoleon, G. Kokotos, ARKIVOC, 2002, 55-61, 2003.
92. "STEREOSELECTIVE INTRAMOLECULAR AZIDE 1,3-DIPOLAR CYCLOADDITION", T. Markidis, E. Mikros, G. Kokotos, Heterocycles, 60, 2367, 2003.
93. “INHIBITION OF GROUP IVA CYTOSOLIC PHOSPHOLIPASE A2 BY NOVEL 2-OXOAMIDES IN VITRO; IN CELLS AND IN VIVO” G. Kokotos, D: Six, V. Loukas, T. Smith, V. Constantinou-Kokotou, D. Hadjipavlou-Litina, S. Kotsovolou, A. Chiou, C. Beltzner and E. Dennis, J. Med. Chem., 47, 3615-3628, 2004.
94. “SYNTHESIS OF NON-NATURAL AMINO ACIDS BASED ON THE RUTHENIUM-CATALYSED OF A PHENYL GROUP TO CARBOXYLIC ACID” P. Moutevelis-Minakakis, C. Sinanoglou, V. Loukas and G. Kokotos, Synthesis, 933-938, 2005.
95. “HOMOGENEOUS CATALYTIC AMINOCARBONYLATION OF IODOALKENES AND IODOBENZENE WITH AMINO ACID ESTERS UNDER CONVENTIONAL CONDITIONS AND IN IONIC LIQUIDS” E. Muller, G. Perczely, R. Skoda-Foldes, E. Takacs, G. Kokotos, E. Bellis, L. Kollar, Tetrahedron, 61, 797-802, 2005.
96. “ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS. 1. CLEVAGE OF THE TERT-BUTYL MOIETY” M. Schmidt, E. Barbayianni, I. Fotakopoulou, M. Hohne, V. Constantinou-Kokotou, U. T. Bornscheuer and G. Kokotos, J. Org. Chem., 70, 3737-3740, 2005.
97. “4- SUBSTITUTED-PROLYL SULFONAMIDES AS ENANTIOSELECTIVE ORGANOCATALYSTS FOR ALDOL REACTIONS” E. Bellis, K. Vasilatou and G. Kokotos, Synthesis, 2407-2413, 2005.
98. “PROLINE-MODIFIED POLY(PROPYLENEIMINE) DENDRIMERS AS CATALYSTS FOR ASYMMETRIC ALDOL REACTIONS” E. Bellis and G. Kokotos, J. Mol. Catal. A: Chem., 241, 166-174, 2005.
99. “4-SUBSTITUTED PROLINES AS ORGANOCATALYSTS FOR ALDOL REACTIONS” E. Bellis and G. Kokotos, Tetrahedron, 61, 8669-8676, 2005.
100. “ENZYMATIC REMOVAL OF CARBOXYL PROTECTING GROUPS. 2. CLEVAGE OF THE BENZYL AND METHYL MOIETIES” E. Barbayianni, I. Fotakopoulou, M. Schmidt, V. Constantinou-Kokotou, U. T. Bornscheuer and G. Kokotos, J. Org. Chem., 70, 8730-8733, 2005.
