Publications
Table of Contents (TOC)
Publications
Table of Contents (TOC)
Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids
ACS Nano 2021, 15(4), 6909–6916. doi: 10.1021/acsnano.0c10683
Abstract
Human bone marrow stromal cells contain skeletal stem cells (SSCs) capable of osteogenic, adipogenic, and chondrogenic differentiation, but their enrichment remains challenging due to the lack of a definitive SSC marker. We designed DNA-gold nanoparticles that target specific mRNA signatures to identify and sort SSCs. This technique enables significant SSC enrichment and offers promising applications in bone biology and regenerative medicine.
For citation:
Xavier, M.; Kyriazi, M.E.; Lanham, S.; Alexaki, K.; Matthews, E.; El-Sagheer, A. H.; Brown, T.; Kanaras, A. G.; Oreffo, R. O. C.
"Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids"
ACS Nano 2021, 15(4), 6909–6916. doi: 10.1021/acsnano.0c10683