Publications
Table of Contents (TOC)
A DNA Sensor Based on Upconversion Nanoparticles and Two-Dimensional Dichalcogenide Materials
Front. Chem. Sci. Eng. 2021, 15(4), 935–943. doi: 10.1007/s11705-020-2023-9
Abstract
We demonstrate the fabrication of a new DNA sensor that is based on the optical interactions occurring between oligonucleotide-coated NaYF₄:Yb³⁺,Er³⁺ upconversion nanoparticles and the two-dimensional dichalcogenide materials, MoS₂ and WS₂. Monodisperse upconversion nanoparticles were functionalized with single-stranded DNA, endowing the nanoparticles with the ability to interact with the surface of the two-dimensional materials via van der Waals interactions, leading to subsequent quenching of the upconversion fluorescence. In contrast, in the presence of a complementary oligonucleotide target and the formation of double-stranded DNA, the upconversion nanoparticles could not interact with MoS₂ and WS₂, thus retaining their inherent fluorescence properties. Utilizing this sensor, we were able to detect target oligonucleotides with high sensitivity and specificity, reaching a concentration detection limit as low as 5 mol L⁻¹, within minutes.
For citation:
Alexaki, K.; Giust, D.; Kyriazi, M. E.; El-Sagheer, A. H.; Brown, T.; Muskens, O. L.; Kanaras, A. G.
"A DNA Sensor Based on Upconversion Nanoparticles and Two-Dimensional Dichalcogenide Materials"
Front. Chem. Sci. Eng. 2021, 15(4), 935–943. doi: 10.1007/s11705-020-2023-9