Publications
Table of Contents (TOC)
Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers
ACS Nano 2018, 12(4), 3333–3340
Abstract
The design of nanoparticulate systems that can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance. Here, we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers capable of multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on designing sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells.
For citation:
Kyriazi, M. E.; Giust, D.; El-Sagheer, A. H.; Lackie, P. M.; Muskens, O. L.; Brown, T.; Kanaras, A. G.
"Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers"
ACS Nano 2018, 12(4), 3333–3340. DOI: 10.1021/acsnano.7b08620