The interactions between noncancerous, primary endothelial cells and gold nanoparticles with different morphologies but of the same ligand capping are presented. Cell viability studies show that all types of gold particles are non-cytotoxic. The number of particles taken up by the cells differs depending on particle morphology. The above results are employed to discuss nanoparticle laser hyperthermia. We find that collective heating effects deriving from several cells loaded with nanoparticles must be included to explain the observed viability of the endothelial cells.
For citations:
Bartczak, D.; Muskens, O. L.; Nitti, S.; Millar, T. M.; Sanchez-Elsner, T.; Kanaras*, A. G.
Interactions of Human Endothelial Cells with Gold Nanoparticles of Different Morphologies
Small, 2012, 8(1), 122-130
DOI: 10.1002/smll.201101422