Magrioti Publications

42. "Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin" D. Vourloumis, I. Mavridis, A. Athanasoulis, I. Temponeras, D. Koumantou, P. Giastas, A. Mpakali, V. Magrioti, J. Leib, P. van Endert, E. Stratikos, A. Papakyriakou, J. Med. Chem. 2022, 65, 10098-10117. [PDF]

41. "Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives" V. Mavrikaki, A. Pagonis, I. Poncin, I. Mallick, S. Canaan, V. Magrioti, J.-F. Cavallier, Bioorg. Med. Chem. Lett. 2022, 64, 128692. [PDF]

40. "α-Ketoheterocycles Able to Inhibit the Generation of Prostaglandin E2 (PGE2) in Rat Mesangial Cells" A. Psarra, M. A. Theodoropoulou, M. Erhardt, M. Mertiri, C. Mantzourani, S. Vasilakaki, V. Magrioti, A. Huwiler, G.Kokotos, Biomolecules 2021, 11, 1-19. [PDF]

39. "Changes in the cellular fatty acid profile drive the proteasomal degradation of α-synuclein and enhance neuronal survival" M. Xylaki, I. Boumpoureka, M. G. Kokotou, T. Marras, G. Papadimitriou, I. Kloukina, V. Magrioti, G. Kokotos, K. Vekrellis, E. Emmanouilidou, FASEB J. 2020, 34, 15123 - 15145. [PDF]

38. "The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A₂s to Adrenic Acid Mobilization in Murine Macrophages" P. Monge, A. Garrido, J. M. Rubio, V. Magrioti, G. Kokotos, M. A. Balboa, J. Balsinde, Biomolecules 2020, 10, 542. [PDF]

37. "Synthesis of pentafluorobenzene-based NHC adducts and their catalytic activity in the microwave-assisted reactions of aldehydes" E. Papadaki, V. Magrioti, Tetrahedron Lett. 2020, 61, 151419. [PDF]

36. "Heteroleptic copper(I) complexes incorporating sterically demanding diazabutadiene ligands (DABs). Synthesis, spectroscopic characterization and solid state structural analysis" A. Peppas, E. Papadaki, G. Schnakenburg, V. Magrioti, A. I. Philippopoulos, Polyhedron 2019, 171, 412-422. [PDF]

35. "β-Lactones: A Novel Class of Ca²⁺-Independent Phospholipase A₂ (Group VIA iPLA₂) Inhibitors with the Ability To Inhibit β-Cell Apoptosis" C. Dedaki, M. G. Kokotou, V. D. Mouchlis, D. Limnios, X. Lei, C. T. Mu, S. Ramanadham, V. Magrioti, E. A. Dennis, G. Kokotos. J. Med. Chem. 2019, 62, 2916?2927. [PDF]

34. "Synthesis of long chain β-lactones and their antibacterial activities against pathogenic mycobacteria" P. Santucci, C. Dedaki, A. Athanasoulis, L. Gallorini, A. Munoz, S. Canaan, J.-F. Cavalier, V. Magrioti, ChemMedChem 2019, 14, 349-358. [PDF]

33. "Microwave-assisted Synthesis of Hydroxymethyl Ketones Using Azolium-2-carboxylate Zwitterions as Catalyst Precursors" E. Papadaki, L. Delaude, V. Magrioti, Tetrahedron 2017, 73, 7295-7300. [PDF]

32. "2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A₂" M. G. Kokotou, G. Galiatsatou,V. Magrioti, G. Koutoulogenis, E. Barbayianni, D. Limnios, V. D. Mouchlis, B. Satpathy, A. Navratil, E. A. Dennis, G. Kokotos Sci. Rep. 2017, 7, 7025. [PDF]

31. "Efficient Microwave-assisted Synthesis of Hydroxymethyl Ketones Using NHC Organocatalysts" A. Nikolaou, G. Kokotos, V. Magrioti Tetrahedron 2016, 72, 7628-7632. [PDF]

30. "2-Oxoamide inhibitors of cytosolic group IVA phospholipase A₂ with reduced lipophilicity" G. Antonopoulou, V. Magrioti, M. G. Kokotou, A. Nikolaou, E. Barbayianni, V. D. Mouchlis, E. A. Dennis, G. Kokotos, Bioorg. Med. Chem. 2016, 24, 4544-4554. [PDF]

29. "Inhibitors of Secreted Phospholipase A₂ Suppress the Release of PGE₂ in Renal Mesangial Cells" S. Vasilakaki, E. Barbayianni, V. Magrioti, O. Pastukhov, V. Constantinou-Kokotou, A. Huwiler, G. Kokotos, Bioorg. Med. Chem. 2016, 24, 3029-3034. [PDF]

28. "Inhibition of Ca²⁺-Independent Phospholipase A₂ (iPLA₂β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice" R. Bone, Y. Gai, V. Magrioti, M. Kokotou, T. Ali, X. Lei, H. Tse, G. Kokotos, S. Ramanadham, Diabetes 2015, 64, 541-554. [PDF]

27. "Inhibition of Group IVA Cytosolic Phospholipase A₂ by Thiazolyl Ketones In Vitro, Ex Vivo, and In Vivo" G. Kokotos, A. J. Feuerherm, E. Barbayianni, I. Shah, M. Sζther, V. Magrioti, T. Nguyen, V. Constantinou-Kokotou, E. A. Dennis, B. Johansen, J. Med. Chem. 2014, 57, 7523-7535. [PDF]

26. "Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A₂s Act on Distinct Phospholipid Pools in Zymosan-Stimulated Mouse Peritoneal Macrophages" L. Gil-de-Gσmez, A. M. Astudillo, C. Guijas, V. Magrioti, G. Kokotos, M. A. Balboa, J. Balsinde, J. Immunol. 2014, 192, 752-762. [PDF]

25. "Characterization of FKGK18 as Inhibitor of Group VIA Ca²⁺-Independent Phospholipase A₂(iPLA₂b): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes" T. Ali, G. Kokotos, V. Magrioti, R. N. Bone, J. A. Mobley, W. Hancock, S. Ramanadham, PLOS ONE 2013, 8, e71748. [PDF]

24. "New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A₂" V. Magrioti, A. Nikolaou, A. Smyrniotou, I. Shah, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos, Bioorg. Med. Chem. 2013, 21, 5823-5829. [PDF]

23. "Autotaxin Inhibitors: A Patent Review" E. Barbayianni, V. Magrioti, P. Moutevelis-Minakakis, G. Kokotos, Exp. Opin. Ther. Patents 2013, 23, 1123-1132. [PDF]

22. "Phospholipase A₂ Inhibitors for the Treatment of Inflammatory Diseases: A Patent Review (2010-present)" V. Magrioti, G. Kokotos, Exp. Opin. Ther. Patents 2013, 23, 333-344. [PDF]

21. "Phospholipase A₂ Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention" E. A. Dennis, J. Cao, Y.-H. Hsu, V. Magrioti, G. Kokotos, Chem. Rev. 2011, 111, 6130-6185. [PDF]

20. "Inhibition of Secreted Phospholipases A₂ by 2-Oxoamides Based on α-Amino Acids: Synthesis, in vitro Evaluation and Molecular Docking Calculations" V. D. Mouchlis, V. Magrioti, E. Barbayianni, N. Cermak, R. S. Oslund, T. M. Mavromoustakos, M. H. Gelb, G. Kokotos, Bioorg. Med. Chem. 2011, 19, 735-743. [PDF]

19. "Resolution of N-Protected Amino Alcohols by Porcine Pancreatic Lipase" V. Magrioti, I. Fotakopoulou, N. Athinaios, P. Anastasopoulou, V. Constantinou-Kokotou, G. Kokotos, Lett. Org. Chem. 2010, 7, 159-162. [PDF]

18. "Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A₂" G. Kokotos, Y.-H. Hsu, J. E. Burke, C. Baskakis, C. G. Kokotos, V. Magrioti, E. A. Dennis, J. Med. Chem. 2010, 53, 3602-3610. [PDF]

17. "Phospholipase A₂ inhibitors as potential therapeutic agents for the treatment of inflammatory diseases" V. Magrioti, G. Kokotos, Exp. Opin. Ther. Patents 2010, 20, 1-18. [PDF]

16. "2-Oxoamide inhibitors of phospholipase A₂ activity and cellular arachidonate release based on dipeptides and pseudodipeptides" E. Barbayianni, D. Stephens, A. Grkovits, V. Magrioti, Y.-H. Hsu, N. Cotton, P. Dolatzas, D. Kalogiannidis, E. A. Dennis, G. Kokotos, Bioorg. Med. Chem. 2009, 17, 4833-4843. [PDF]

15. "Differing roles for members of the phospholipase A₂ superfamily in experimental autoimmune encephalomyelitis" A. Kalyvas, C. Baskakis, V. Magrioti, V. Constantinou-Kokotou, D. Stephens, R. Lopez-Vales, J.-Q. Lu, V. Yong, E. A. Dennis, G. Kokotos, S. David, Brain 2009, 132, 1221-1235. [PDF]

14. "Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A₂ enzymes" G. Antonopoulou, E. Barbayianni, V. Magrioti, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos, Bioorg. Med. Chem. 2008, 16, 10257-10269. [PDF]

13. "A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity" V. Magrioti, G. Naxakis, D. Hadjipavlou-Litina, A. Makriyannis, G. Kokotos, Bioorg. Med. Chem. Lett. 2008, 18, 5424-5427. [PDF]

12. "Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A₂ enzymes" C. Baskakis, V. Magrioti, N. Cotton, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos, J. Med. Chem. 2008, 51, 8027-8037. [PDF]

11. "Synthesis of 2-oxoamides based on sulfonamide analogs of γ-amino acids and their activity on phospholipase A₂" G. Antonopoulou, V. Magrioti, D. Stephens, V. Constantinou-Kokotou, E. A. Dennis, G. Kokotos, J. Pept. Sci. 2008, 14, 1111-1120. [PDF]

10. "Structure-activity relationship of 2-oxoamide inhibition of Group IVA cytosolic phospholipase A₂ and Group V secreted phospholipase A₂" D. A. Six, E. Barbayianni, V. Loukas, V. Constantinou-Kokotou, D. Hadjipavlou-Litina, D. Stephens, A. C. Wong, V. Magrioti, P. Moutevelis-Minakakis, S. F. Baker, E. A. Dennis, G. Kokotos, J. Med. Chem. 2007, 50, 4222-4235. [PDF]

9. "Synthetic inhibitors of group IVA and group VIA phospholipase A₂" V. Magrioti, G. Kokotos, Anti-inflammatory Anti-allergy Agents Med. Chem. 2006, 5, 189-203. [PDF]

8. "Sterically hindered triacylglycerol analogues as potent inhibitors of human digestive lipases" V. Constantinou-Kokotou, V. Magrioti, R. Verger, Chem. Eur. J. 2004, 10, 1133-1140. [PDF]

7. "Triacylglycerols based on 2-(N-tert-butoxycarbonylamino)-oleic acid are potent inhibitors of pancreatic lipase" V. Magrioti, R. Verger, V. Constantinou-Kokotou, J. Med. Chem.2004, 47, 288-291. [PDF]

6. "Synthesis of 2-amino alcohols and unnatural amino acids from serine" V. Magrioti, G. Antonopoulou, E. Pantoleon, G. Kokotos, ARKIVOC 2003, 2002, 55-61. [PDF]

5. "Synthesis and use of N,N-di-Boc-glutamate γ-semialdehydes and related aldehydes" V. Constantinou-Kokotou, V. Magrioti, Amino Acids 2003, 24, 231-243. [PDF]

4. "Synthesis and in vivo anti-inflammatory activity of long-chain 2-amino-alcohols" V. Magrioti, D. Hadjipavlou-Litina, V. Constantinou-Kokotou, Bioorg. Med. Chem. Lett. 2003, 13, 375-377. [PDF]

3. "Synthesis of (S)-α-amino oleic acid" V. Magrioti, V. Constantinou-Kokotou, Lipids 2002, 37, 223-228. [PDF]

2. "Synthesis of enantiopure non-natural α-amino acids using tert-butyl (2S)-2-[bis-(tert-butyloxycarbonyl)amino]-5-oxo-pentanoate as key intermediate: The first synthesis of (S)-2-amino oleic acid" V. Constantinou-Kokotou, V. Magrioti, T. Markidis, G. Kokotos, J. Peptide Res. 2001, 58, 325-331. [PDF]

1. "Study of DNA interactions with melphalan, busulphan and analogues using an HPLC method" G. A. Karikas, V. Constantinou-Kokotou, V. Magrioti, G. Kokotos, J. Liq. Chromatogr. & Related Technol. 2000, 23, 1859-1864. [PDF]

blank