Home CV Publications Photos

Laboratory of Organic Chemistry

Department of Chemistry

University of Athens

Panepistimiopolis 15771

Athens, Greece


Tel: +30-2107274281

Fax: +30-2107274461

Email: ckokotos@chem.uoa.gr

Christoforos G. Kokotos Athens Organocatalysis Group Publications

55) “Organocatalytic Synthesis of Lactones via an Oxidation of Alkenoic-acids” I. Triandafillidi, M. Raftopoulou A. Savvidou, C. G. Kokotos*, ChemCatChem, 2017, accepted for publication.

















54) “Visible-Light-Mediated Catalytic Hydroacylation of Dialkyl Azodicarboxylates by Graphite Flakes” G. S. Koutoulogenis, M. G. Kokotou, E. Voutyritsa, D. Limnios, C. G. Kokotos*, Org Lett., 2017, 19, 1760-1763.










53) “Organocatalytic oxidation of substituted anilines to azoxybenzenes and nitro compounds: mechanistic studies excluding the involvement of a dioxirane intermediate” E. Voutyritsa, A. Theodorou, M. G. Kokotou, C. G. Kokotos*, Green Chem., 2017, 19, 1291-1298. 2017 Green Chemistry Hot












52) “Green Organocatalytic Synthesis of Indolines and Pyrrolidines from Alkenes” A. Theodorou, C. G. Kokotos*, Adv. Synth. Catal., 2017, 359, 15771-1581.













51) “Green Organocatalytic Synthesis of Isoxazolines via a One-Pot Oxidation of Allyloximes” I. Triandafillidi, C. G. Kokotos*, Org. Lett., 2017, 19, 106-109.











50) “Photoinitiated Thiol-Ene “Click” Reaction: An Organocatalytic Alternative” D. Limnios, C. G. Kokotos*, Adv. Synth. Catal., 2017, 359, 323-328.













49) “Organocatalytic synthesis of polysubstituted tetrahydrofurans from alkenes” A. Theodorou, C. G. Kokotos*, Green Chem., 2017, 19, 670-674.














48) “Green Organocatalytic Dihydroxylation of Alkenes” A. Theodorou, I. Triandafillidi, C. G. Kokotos*, Eur. J. Org. Chem., 2017, 1502-1509.














47) “Green Organocatalytic Oxidation of Sulfides to Sulfoxides and Sulfones” E. Voutyritsa, I. Triandafillidi, C. G. Kokotos*, Synthesis, 2017, 49, 917-924. Invited Contribution for Burgenstock Conference












46) “Enantioselective Organocatalytic Synthesis of 2-Oxopiperazines from Aldehydes: Identification of the Elusive Epoxy Lactone Intermediate” N. Kaplaneris, C. Spyropoulos, M. G. Kokotou, C. G. Kokotos*, Org. Lett., 2016, 18, 5800-5803.












45) One-Pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes” G. N. Papadopoulos, C. G. Kokotos*, J. Org. Chem., 2016, 81, 7023-7028.












44) “Photoorganocatalytic one-pot synthesis of hydroxamic acids from aldehydes” G. N. Papadopoulos, C. G. Kokotos*, Chem. Eur. J., 2016, 22, 6964-6967.










43) “Green organocatalytic á-hydroxylation of ketones” E. Voutyritsa, A. Theodorou, C. G. Kokotos*, Org. Biomol. Chem., 2016, 14, 5708-5713. Invited Article for the Special Thematic issue “New Talent in Organic and Medicinal Chemistry”.













42) “(Thio)urea-mediated synthesis of functionalized six-membered rings with multiple chiral centers” G. Koutoulogenis, N. Kaplaneris, C. G. Kokotos*, Beilstein J. Org. Chem., 2016, 12, 462-495. Invited Article for the Special issue “Multifunctional Organocatalysis”.














41) “4-Fluoro and 4-hydroxy pyrrolidine-thioxotetrahydropyrimidinones: Organocatalysts for green asymmetric transformations in brine” N. Kaplaneris, G. Koutoulogenis, M. Raftopoulou, C. G. Kokotos*, J. Org. Chem., 2015, 80, 5464-6473.















40) tert-Butyl esters of peptides as organocatalysts for the asymmetric aldol reaction” A. Bisticha, I. Triandafillidi, C. G. Kokotos*, Tetrahedron: Asymmetry, 2015, 26, 102-108.











39) “One-pot synthesis of O-allylhydroxylamines through the organocatalytic oxidation of tertiary allylic amines followed by a [2,3]-Meisenheimer rearrangement” A. Theodorou, D. Limnios, C. G. Kokotos*, Chem. Eur. J., 2015, 21, 5238-5241.












38) tert-Butyl ester or benzylamide of the dipeptide Pro-Gly as organocatalysts for the asymmetric aldol reaction” I. Triandafillidi, A. Bisticha, E. Voutyritsa, G. Galiatsatou, C. G. Kokotos*, Tetrahedron, 2015, 71, 932-940.











37) “Conjugating proline derivatives onto multi-walled carbon nanotubes: Preparation, characterization and catalytic activity in water” D. D. Chronopoulos, C. G. Kokotos, M. Tsakos, N. Karousis, G. Kokotos, N. Tagmatarchis, Mat. Lett., 2015, 157, 212-214.











36) “Functionalized multi-walled carbon nanotubes in an aldol reactions” D. D. Chronopoulos, C. G. Kokotos, N. Karousis, G. Kokotos*, N. Tagmatarchis*, Nanoscale, 2015, 7, 2750-2757.













35) “Organocatalytic Oxidation Reactions” D. Limnios, C. G. Kokotos*, Current Organocatalysis, 2015, 2, 171-190.
















34) “Fullerene-proline hybrids: Synthesis, characterization and organocatalytic properties in aldol reactions” D. D. Chronopoulos, M. Tsakos, N. Karousis, C. G. Kokotos*, N. Tagmatarchis*, Mat. Lett., 2014, 137, 343-346.













33) “Photoorganocatalytic hydroacylation of dialkyl azodicarboxylates by utilizing activated ketones as photocatalysts” G. N. Papadopoulos, D. Limnios, C. G. Kokotos*, Chem. Eur. J., 2014, 20, 13811-13814.











32) “2,2,2-Trifluoroacetophenone: An organocatalyst for an environmentally friendly epoxidation of alkenes” D. Limnios, C. G. Kokotos*, J. Org. Chem., 2014, 79, 4270-4276. Feature Article, ACS Editors Choice Article, Top Read Article for the last 12 months, Highlighted at TCI catalogue for 2,2,2-trifluoroacetophenone.











31) “One-pot synthesis of ureas from Boc-protected amines” C. Spyropoulos, C. G. Kokotos*, J. Org. Chem., 2014, 79, 4477-4483.







30) “2,2,2-Trifluoroacetophenone as an organocatalyst for the oxidation of tertiary amines and azines to N-oxides” D. Limnios, C. G. Kokotos*, Chem. Eur. J., 2014, 20, 559-563.










29) tert-Butyl esters of tripeptides based on Pro-Phe as organocatalysts for the asymmetric aldol reaction in aqueous or organic medium” A. Psarra, C. G. Kokotos*, P. Moutevelis-Minakakis*, Tetrahedron, 2014, 70, 608-615.










28) “Primary and secondary amine-(thio)ureas and squaramides and their applications in asymmetric organocatalysis” M. Tsakos, C. G. Kokotos*, Tetrahedron, 2013, 69, 10199-10222.








27) “Organocatalytic oxidation of organosilanes to silanols” D. Limnios, C. G. Kokotos*, ACS Catalysis, 2013, 3, 2239-2243.








26) “β-tert-Butyl Aspartate as an Organocatalyst for the Asymmetric α-Amination of α,α-Disubstituted Aldehydes” A. Theodorou, G. N. Papadopoulos and C. G. Kokotos*, Tetrahedron, 2013, 69, 5438-5443.











25) “An Asymmetric Michael Addition of α,α-Disubstituted Aldehydes to Maleimides leading to a One-pot Enantioselective Synthesis of Lactones Catalyzed by Amino Acids” C. G. Kokotos*, Org. Lett., 2013, 15, 2406-2409.












24) “Microwave-Assisted Organocatalytic Cross-Aldol Condensation of Aldehydes” D. Limnios, C. G. Kokotos*, RSC Adv., 2013, 3, 4496-4499.











23) “Organocatalytic Asymmetric Domino Michael-Henry reaction for the Synthesis of Substituted Bicyclo[3.2.1]octan-2-ones” M. Tsakos, M. R. J. Elsegood, C. G. Kokotos*, Chem. Commun., 2013, 49, 2219-2221.












22) “Novel Prolinamide-Ureas as Organocatalysts for the Asymmetric Aldol Reaction” P. Revelou, C. G. Kokotos*, P. Moutevelis-Minakakis*, Tetrahedron, 2012, 68, 8732-8738.



 








21) “Pyrrolidine-thioxotetrahydropyrimidinone as an Efficient Organocatalyst for the Enantioselective Michael Addition of Cyclic Ketones to Nitrodienes” M. Tsakos. M. Trifonidou, C. G. Kokotos*, Tetrahedron, 2012, 68, 8630-8635.



 







20) “A Tripeptide-like Prolinamide-Thiourea as an Aldol Reaction Catalyst” S. Fotaras, C. G. Kokotos, G. Kokotos, Org. Biomol. Chem., 2012, 10, 5613-5619.










19) “Primary Amine-Thioureas with Improved Catalytic Properties for “Difficult” Michael Reactions. Efficient Organocatalytic Syntheses of (S)-, (R)-Baclofen and (S)-Phenibut” M. Tsakos, C. G. Kokotos, G. Kokotos, Adv. Synth. Catal., 2012, 354, 740-746.










18) “Enantioselective Organocatalytic α-Alkylation of Ketones Utilising SN-1 Type Reaction of Alcohols” M. Trifonidou, C. G. Kokotos*, Eur. J. Org. Chem., 2012, 1563-1568.









17) “Construction of Tertiary Alcohols Bearing Perfluoroalkyl Chains Catalyzed by Prolinamide-Thioureas” C. G. Kokotos*, J. Org. Chem., 2012, 77, 1131-1135.












16) “Organocatalytic “Difficult” Michael Reaction of Ketones with Nitrodienes Utilising Primary Amine-Thioureas Based on di-tert-Butyl Esters of Aspartic Acid” M. Tsakos, C. G. Kokotos*, Eur. J. Org. Chem., 2012, 576-580.










15) “Novel pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as highly effective catalysts for the asymmetric Michael addition” C. G. Kokotos, D. Limnios, D. Triggidou, M. Trifonidou, G. Kokotos, Org. Biom. Chem., 2011, 9, 3386-3395.











14) “Prolinamides bearing thiourea groups as catalysts for asymmetric aldol reactions” S. Fotaras, C. G. Kokotos, E. Tsandi, G. Kokotos, Eur. J. Org. Chem., 2011, 1310-1317.











13) “Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2” G. Kokotos, Y.-H. Hsu, J. Burke, C. Baskakis, C. G. Kokotos, V. Magrioti, E. A. Dennis, J. Med. Chem., 2010, 53, 3602-3610.







12) “Interactions at the bilayer interface and receptor site induced by the novel synthetic pyrrolidinone analog MMK3” C. Fotakis, S. Gega, E. Siapi, C. Potamitis, K. Viras, P. Moutevelis-Minakakis, C. G. Kokotos, S. Durdagi, S. Golic Grdadolnik, B. Sartori, M. Rappolt, T. Mavromoustakos, Biochim. Biophys. Acta Biomembranes, 2010, 1798, 422-432.



11) Bacillus subtilis esterase (BS2) and its double mutant have different selectivity in the removal of carboxyl protecting groups” E. Barbayianni, C. G. Kokotos, S. Bartsch, C. Drakou, U. Bornscheuer, G. Kokotos, Adv. Synth. Catal., 2009, 351, 2325-2332.












10) “Primary amine-thioureas based on tert-butyl esters of natural amino acids as organocatalysts for the Michael reaction” C. G. Kokotos, G. Kokotos, Adv. Synth. Catal., 2009, 351, 1355-1362.







9) “Sulfonamides of homoproline and dipeptides as organocatalysts for Michael and aldol reactions” E. Tsandi, C. G. Kokotos, S. Kousidou, V. Ragoussis, G. Kokotos, Tetrahedron, 2009, 65, 1444-1449.







8) “Synthesis of medicinally interesting polyfluoro ketones via perfluoroalkyl lithium reagents” C. G. Kokotos, C. Baskakis, G. Kokotos, J. Org. Chem., 2008, 73, 8623-8626.







7) “Sulfur ylide mediated three-component aziridination and epoxidation reactions using vinyl sulfonium salts” C. G. Kokotos, E. M. McGarrigle, V. K. Aggarwal, Synlett, 2008, 2191-2195, highlighted in Synfacts, 2008, 11, 1142.








6) “Aminals as substrates for sulfur ylides: A synthesis of functionalised aziridines and N-heterocycles” C. G. Kokotos, V. K. Aggarwal, Org. Lett., 2007, 9, 2099-2102.









5) “A practical synthesis of a [2.2.1] bicyclic chiral sulfide for asymmetric transformations” V. K. Aggarwal, G. Fang, C. G. Kokotos, J. Richardson, M. G. Unthank, Tetrahedron, 2006, 62, 11297-11303.








4) “Hemi-aminals as substrates for sulfur ylides: Direct asymmetric syntheses of functionalised pyrrolidines and piperidines” C. G. Kokotos, V. K. Aggarwal, Chem. Commun., 2006, 2156-2158.


 










3) “Synthesis, binding studies, and in vivo biological evaluation of novel non-peptide antihypertensive analogues” T. Mavromoustakos, P. Moutevelis-Minakakis, C. G. Kokotos, P. Kontogianni, A. Politi, P. Zoumpoulakis, J. Findlay, A. Cox, A. Balmforth, A. Zoga, E. Iliodromitis, Bioorg. Med. Chem., 2006, 14, 4353-4360.











2) “Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal PGE2 release” T. L. Yaksh, G. Kokotos, C. I. Svensson, D. Stephens, C. G. Kokotos, B. Fitzsimmons, D. Hadjipavlou-Litina, X. Y. Hua, E. A. Dennis, J. Pharmacol. Exp. Ther., 2006, 316, 466-475


1) “Synthesis and activity of 2-oxoamides containing long chain β-amino acids” V. Constantinou-Kokotou, A. Peristeraki, C. G. Kokotos, D. A. Six, E. A. Dennis, J. Peptide Sci., 2005, 11, 431-435.




Patents


2) “Pyrrolidine-thioxopyrimidinone/thiohydantion organocatalysts” G. Kokotos, C. G. Kokotos, D. Limnios, European Patent application, EP10386007. 8, 19-3-2010.


1) “Perfluoroketone compounds and uses thereof” S. David, A. Kalyvas, R. Lopez-Vales, G. Kokotos, V. Constantinou-Kokotou, C. Baskakis, C. G. Kokotos, D. Stephens, E. A. Dennis, WO 2008122119 A1, 2008-10-16.


“There is nothing impossible to him who will try”  Alexander the Great