Surfactin Conjugated Silver Nanoparticles as an Antibacterial and Antibiofilm Agent against Pseudomonas aeruginosa

ACS Appl. Mater. Interfaces 2023, 15 (37), 43321-43331

Abstract

The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multidrug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the synthesis and application of surfactin-coated silver nanoparticles as an efficient antibacterial and antibiofilm agent against drug-resistant Pseudomonas aeruginosa for safe dermal applications. Our in vivo studies showed no significant superficial dermal irritation, edema, or erythema, whilst microscopic analysis revealed that surfactin-coated silver nanoparticles caused no pathological alterations at the applied concentrations. These results support the potential use of surfactin-coated silver nanoparticles against drug-resistant bacterial biofilm infections and in skin wound dressing applications.

For citation:
Rahman, L.; Sarwar, Y.; Khaliq, S.; Inayatullah; Abbas, W.; Mobeen, A.; Ullah, A.; Hussain, S. Z.; Khan, W. S.; Kyriazi, M. E.; Hussain, I.; Kanaras, A. G.; Rehman, A.
"Surfactin Conjugated Silver Nanoparticles as an Antibacterial and Antibiofilm Agent against Pseudomonas aeruginosa"
ACS Appl. Mater. Interfaces 2023, 15 (37), 43321-43331. doi: 10.1021/acsami.3c07071

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