Publications
Table of Contents (TOC)
Receptor-Mediated Interactions between Colloidal Gold Nanoparticles and Human Umbilical Vein Endothelial Cells
Small, 2011, 7, No. 3, 388-394
Abstract
A new strategy to manipulate cell operations is demonstrated based upon membrane-receptor specific interactions between colloidal peptide-capped gold nanoparticles and human umbilical vein endothelial cells. It is shown that colloidal gold nanoparticles of similar charge and size but capped with different peptide sequences can deliberately trigger specific cell functions related to the important biological process of blood vessel growth known as angiogenesis. We achieved the specific binding of the peptide-capped particles to two endothelial expressed receptors (VEGFR-1, NRP-1), which control angiogenesis, imaged the cellular fate of the functional nanoparticles, and monitored the influence of the different peptide-coated nanoparticles on the gene expression profile of hypoxia-related and angiogenic genes. Our findings open up new avenues towards the deliberate biological control of cellular functions using strategically designed nanoparticles.
For citations:
Bartczak, D.; Sanchez-Elsner, T.; Louafi, F.; Millar, T.; Kanaras* A. G.
Receptor-mediated interactions between colloidal gold nanoparticles and human umbilical vein endothelial cells
Small, 2011, 7, No. 3, 388-394
DOI: 10.1002/smll.201001816