We present a novel nanoparticle building block system based on the interactions between short synthetic oligonucleotides and peptides. Gold nanoparticles coated with DNA-binding peptides can be attached to self-organized oligonucleotide templates to formulate well-ordered structures of nanoparticles. By regulating the amount of DNA-binding peptide attached to the nanoparticle surface and using specifically designed oligonucleotides, the nanoparticle assembly can be controlled to form dimers, trimers, adjustable-length nanoparticle chains, as well as more complex structures.
For citations:
Coomber, D.; Bartczak, D.; Gerrard, S.R.; Tyas, S.; Kanaras*, A.G.; Stulz*, E.
Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates
Langmuir 2010, 26 (17), 13760-13762
DOI: 10.1021/la1023554